Detailed information of TA system TA049069

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 360794..361463
• Replicon: chromosome
• Accession: NZ_CP009458
• Organism: Cedecea neteri strain M006

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LH23_RS01610
• Protein ID: WP_039287499.1
• Coordinates: 360794..361216 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1X7KKT1
• Locus tag: LH23_RS01615
• Protein ID: WP_008461626.1
• Coordinates: 361197..361463 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH23_RS01590	356794..358527	-	1734	WP_039287484.1	single-stranded-DNA-specific exonuclease RecJ	-
LH23_RS01595	358534..359250	-	717	WP_039287493.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LH23_RS01600	359277..360173	-	897	WP_039287495.1	site-specific tyrosine recombinase XerD	-
LH23_RS01605	360276..360797	+	522	WP_039287497.1	flavodoxin FldB	-
LH23_RS01610	360794..361216	-	423	WP_039287499.1	protein YgfX	Toxin
LH23_RS01615	361197..361463	-	267	WP_008461626.1	FAD assembly factor SdhE	Antitoxin
LH23_RS01620	361711..362697	+	987	WP_039287510.1	tRNA-modifying protein YgfZ	-
LH23_RS01625	362756..363409	-	654	WP_008461624.1	hemolysin III family protein	-
LH23_RS01630	363584..364177	+	594	WP_039287514.1	HD domain-containing protein	-
LH23_RS01635	364220..364948	+	729	WP_039287523.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16578.56 Da
• Isoelectric Point: 11.7122

>T49069 WP_039287499.1 NZ_CP009458:c361216-360794 [Cedecea neteri]
VVLWQSDLRVSWRAQWMSLLLHGLVALFVLLMPWPMSYTLVWMLLLSLVVFDSVRSQRRIHARQGEIKLLTDFRLRWQGR
DWDIVGNPWMIDSGVMLRLRRAGKHRCQHLWLAADSMDIGEWRDLRRLLMQQQASGSGQI

Nucleotide

• Length: 423 bp

>T49069 NZ_CP009458:c361216-360794 [Cedecea neteri]
GTGGTCCTGTGGCAATCTGATCTGCGGGTTTCATGGCGCGCGCAATGGATGTCATTGCTTCTCCACGGCCTGGTGGCGCT
GTTCGTGCTGCTAATGCCGTGGCCAATGAGCTATACGCTCGTCTGGATGTTGCTGCTTTCCCTTGTGGTTTTCGACAGCG
TGCGCAGCCAGCGCCGCATTCACGCGCGCCAGGGCGAAATTAAACTGCTGACGGACTTTCGTCTGCGTTGGCAGGGGCGT
GACTGGGATATCGTCGGAAATCCGTGGATGATTGACAGTGGGGTGATGCTAAGACTGCGTCGTGCCGGAAAACATCGCTG
TCAGCATCTGTGGCTGGCTGCTGACAGCATGGACATCGGTGAATGGCGAGATCTACGCCGCCTGCTGATGCAGCAACAGG
CGAGCGGAAGCGGGCAGATTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10385.88 Da
• Isoelectric Point: 5.6202

>AT49069 WP_008461626.1 NZ_CP009458:c361463-361197 [Cedecea neteri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYETLSDSDKQLFVRLLESDDPDLFNWLMNHGKPADAELQRMVALIQTRN
KERGPVAI

Nucleotide

• Length: 267 bp

>AT49069 NZ_CP009458:c361463-361197 [Cedecea neteri]
ATGGATATCAATAATAAAGCCCGAATTCACTGGGCATGCCGCCGTGGAATGCGCGAGCTCGATATTTCGATTATGCCGTT
CTTCGAACATGAATATGAAACGCTCAGCGACAGCGATAAGCAGCTGTTTGTTCGCCTGCTGGAATCTGACGATCCAGACC
TGTTTAACTGGTTGATGAATCACGGTAAACCAGCAGATGCCGAGCTTCAGCGTATGGTTGCCCTGATTCAGACACGGAAT
AAAGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X7KKT1