Detailed information of TA system TA049064

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3837580..3838252
• Replicon: chromosome
• Accession: NZ_CP009456
• Organism: Yersinia enterocolitica strain FORC_002

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LI89_RS17435
• Protein ID: WP_019078987.1
• Coordinates: 3837580..3838005 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7U7FJE4
• Locus tag: LI89_RS17440
• Protein ID: WP_004390965.1
• Coordinates: 3837986..3838252 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI89_RS17415	3833341..3833859	+	519	WP_019078984.1	flavodoxin FldB	-
LI89_RS17420	3833931..3835352	-	1422	WP_046694580.1	cell envelope integrity protein CreD	-
LI89_RS17425	3835444..3836871	-	1428	WP_019078986.1	two-component system sensor histidine kinase CreC	-
LI89_RS17430	3836882..3837580	-	699	WP_011817024.1	two-component system response regulator CreB	-
LI89_RS17435	3837580..3838005	-	426	WP_019078987.1	protein YgfX	Toxin
LI89_RS17440	3837986..3838252	-	267	WP_004390965.1	FAD assembly factor SdhE	Antitoxin
LI89_RS17445	3838518..3839510	+	993	WP_046694579.1	tRNA-modifying protein YgfZ	-
LI89_RS17450	3839543..3840226	-	684	WP_019082407.1	hemolysin III family protein	-
LI89_RS17455	3840464..3841066	+	603	WP_011817027.1	HD domain-containing protein	-
LI89_RS17460	3841079..3841828	-	750	WP_019078990.1	SDR family oxidoreductase	-
LI89_RS17465	3841844..3842281	-	438	WP_046694578.1	lipocalin-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16453.27 Da
• Isoelectric Point: 10.1703

>T49064 WP_019078987.1 NZ_CP009456:c3838005-3837580 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQRTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T49064 NZ_CP009456:c3838005-3837580 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ACTGACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGTTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACGGACAAGTAGTCGCTCAAC
CCGTAAGCGTTTATGGTTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGTTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10491.01 Da
• Isoelectric Point: 5.1405

>AT49064 WP_004390965.1 NZ_CP009456:c3838252-3837986 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT49064 NZ_CP009456:c3838252-3837986 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U7FJE4