Detailed information of TA system TA049055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2268107..2269067
• Replicon: chromosome
• Accession: NZ_CP009456
• Organism: Yersinia enterocolitica strain FORC_002

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LI89_RS10270
• Protein ID: WP_019079355.1
• Coordinates: 2268107..2268565 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LI89_RS10275
• Protein ID: WP_046695019.1
• Coordinates: 2268621..2269067 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI89_RS10240	2263855..2264520	+	666	WP_046695022.1	phage shock protein PspA	-
LI89_RS10245	2264749..2264976	+	228	WP_019079351.1	envelope stress response membrane protein PspB	-
LI89_RS10250	2264985..2265380	+	396	WP_161803522.1	envelope stress response membrane protein PspC	-
LI89_RS10255	2265426..2265665	+	240	WP_005169543.1	phage shock protein PspD	-
LI89_RS10260	2265646..2267043	+	1398	WP_046050953.1	YcjX family protein	-
LI89_RS10265	2267040..2268104	+	1065	WP_046695020.1	YcjF family protein	-
LI89_RS10270	2268107..2268565	-	459	WP_019079355.1	RES family NAD+ phosphorylase	Toxin
LI89_RS10275	2268621..2269067	-	447	WP_046695019.1	DUF2384 domain-containing protein	Antitoxin
LI89_RS10280	2269387..2270970	+	1584	WP_019079357.1	transcriptional regulator TyrR	-
LI89_RS10285	2271054..2271557	-	504	WP_005161000.1	thiol peroxidase	-
LI89_RS10290	2271710..2272681	+	972	WP_019083076.1	L-Ala-D/L-Glu epimerase	-
LI89_RS10295	2272678..2273385	-	708	WP_046695018.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17205.62 Da
• Isoelectric Point: 4.6956

>T49055 WP_019079355.1 NZ_CP009456:c2268565-2268107 [Yersinia enterocolitica]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTDWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T49055 NZ_CP009456:c2268565-2268107 [Yersinia enterocolitica]
ATGATGCTCTACCGCATTGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACGTTGGTACATATTC
AGGACAGCTCAACACTAAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAG
GATTGGCCCACGGACTGGCGCAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAGTCAGAATC
ATCACTTGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTACTGCTCAATCCTCGGCACAAAAGCTTTC
AAGCCTGCCTAAGCAGTGTTCAACCGCTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16267.69 Da
• Isoelectric Point: 9.1260

>AT49055 WP_046695019.1 NZ_CP009456:c2269067-2268621 [Yersinia enterocolitica]
MRTYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT49055 NZ_CP009456:c2269067-2268621 [Yersinia enterocolitica]
ATGAGAACATATCACCCCACTCCAGCGACCAAAACAGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCGAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATCCATCTATGGGCATCAATCCCCAAAG
CTGAAATCTTGCGTGCGACCGGCATTCCCAGCCGCAGCTTGACTCGCAGACGCACACATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGAATTGCGCGTTTTGTTCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGTCACCGTAGTCCGGATTCCTTACTGGAAACCGAAACCGGTGCATTGG
AAGTCTGTGATTTGATTGGACGCCTGGAGCACGGCGTATTTTCATAA