Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1244028..1244646 Replicon chromosome
Accession NZ_CP009456
Organism Yersinia enterocolitica strain FORC_002

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag LI89_RS05420 Protein ID WP_002208622.1
Coordinates 1244028..1244231 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6TU35
Locus tag LI89_RS05425 Protein ID WP_005167670.1
Coordinates 1244278..1244646 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI89_RS05390 1239415..1239753 + 339 WP_002208627.1 P-II family nitrogen regulator -
LI89_RS05395 1239793..1241082 + 1290 WP_005167660.1 ammonium transporter AmtB -
LI89_RS05400 1241177..1242040 - 864 WP_019082546.1 acyl-CoA thioesterase II -
LI89_RS05405 1242298..1242828 + 531 WP_046051452.1 YbaY family lipoprotein -
LI89_RS05410 1242880..1243185 - 306 WP_046695714.1 MGMT family protein -
LI89_RS05420 1244028..1244231 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
LI89_RS05425 1244278..1244646 - 369 WP_005167670.1 Hha toxicity modulator TomB Antitoxin
LI89_RS05430 1244804..1245157 - 354 WP_046695349.1 hypothetical protein -
LI89_RS05435 1245751..1245930 + 180 WP_020424140.1 hypothetical protein -
LI89_RS05440 1245927..1246655 + 729 WP_019081288.1 ABC transporter ATP-binding protein -
LI89_RS05445 1246652..1247509 + 858 WP_005163445.1 metal ABC transporter permease -
LI89_RS05450 1247558..1248436 + 879 WP_046695348.1 metal ABC transporter substrate-binding protein -
LI89_RS05455 1248564..1248707 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
LI89_RS05460 1248723..1248983 - 261 WP_019081286.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49054 WP_002208622.1 NZ_CP009456:c1244231-1244028 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49054 NZ_CP009456:c1244231-1244028 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14134.86 Da        Isoelectric Point: 4.4085

>AT49054 WP_005167670.1 NZ_CP009456:c1244646-1244278 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT49054 NZ_CP009456:c1244646-1244278 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6L1C1

References