Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3428744..3429783 Replicon chromosome
Accession NZ_CP009455
Organism Pseudomonas cremoricolorata strain ND07

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A089WQ35
Locus tag LK03_RS15675 Protein ID WP_038413298.1
Coordinates 3429208..3429783 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A089WN43
Locus tag LK03_RS15670 Protein ID WP_038413297.1
Coordinates 3428744..3429208 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK03_RS15650 3423949..3424884 + 936 WP_038413292.1 catechol 1,2-dioxygenase -
LK03_RS15655 3425144..3426496 + 1353 WP_038413294.1 MFS transporter -
LK03_RS15660 3426549..3427655 + 1107 WP_038413296.1 NAD/NADP octopine/nopaline dehydrogenase family protein -
LK03_RS15665 3427694..3428630 + 937 Protein_3093 3-hydroxyacyl-CoA dehydrogenase -
LK03_RS15670 3428744..3429208 + 465 WP_038413297.1 helix-turn-helix domain-containing protein Antitoxin
LK03_RS15675 3429208..3429783 + 576 WP_038413298.1 PIN domain-containing protein Toxin
LK03_RS15680 3429797..3430423 - 627 WP_038413300.1 NIPSNAP family protein -
LK03_RS15685 3430599..3431852 - 1254 WP_205621246.1 MFS transporter -
LK03_RS15690 3431919..3433163 - 1245 WP_038413303.1 OprD family porin -
LK03_RS15695 3433273..3434232 - 960 WP_038413305.1 PDR/VanB family oxidoreductase -
LK03_RS15700 3434243..3434719 - 477 WP_038413307.1 aromatic-ring-hydroxylating dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21804.22 Da        Isoelectric Point: 5.2747

>T49053 WP_038413298.1 NZ_CP009455:3429208-3429783 [Pseudomonas cremoricolorata]
MRQSPFTVVYDACVLYPAPLRDLLMHLALTGVYRARWSEDIHAEWTRNLLKNRPELRPEQLAWTVKCMNDVIADSVVSDY
QSLIPGLQLPDADDRHVLAAAIRCNASVIVTYNLKDFPAEVLRGFEIEALHPDVFLSDIWDLDQAAVLQAARGQRAMLKN
PPYAPRQLLDTLLKQQLPELVKRLSDYELLI

Download         Length: 576 bp

>T49053 NZ_CP009455:3429208-3429783 [Pseudomonas cremoricolorata]
ATGAGGCAGTCGCCCTTCACCGTCGTTTACGACGCTTGTGTTCTGTACCCCGCCCCGCTGCGTGATCTATTGATGCACCT
GGCCTTGACCGGTGTGTATCGAGCACGCTGGTCTGAAGACATCCACGCCGAATGGACACGCAACCTGCTCAAGAACCGCC
CTGAGCTCAGGCCTGAGCAACTGGCCTGGACCGTCAAATGCATGAATGATGTGATCGCTGATTCTGTGGTCAGCGACTAT
CAGTCGCTGATACCTGGCCTGCAGTTGCCAGACGCGGATGATCGCCACGTGCTGGCGGCTGCGATCAGATGCAACGCATC
GGTCATCGTGACCTACAACCTGAAAGACTTCCCCGCAGAGGTGTTGAGAGGTTTCGAAATCGAGGCGCTGCATCCGGATG
TATTTCTGTCCGATATCTGGGATCTCGATCAGGCGGCAGTGCTGCAGGCGGCTCGGGGGCAGCGGGCGATGCTGAAGAAC
CCCCCTTACGCGCCGCGGCAGTTGCTGGACACATTGCTCAAGCAGCAACTGCCAGAGCTGGTGAAACGTCTATCTGACTA
CGAACTATTGATCTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16976.24 Da        Isoelectric Point: 5.9862

>AT49053 WP_038413297.1 NZ_CP009455:3428744-3429208 [Pseudomonas cremoricolorata]
MNTADYSQSVLPDSKTIGAAVESSRQLAAFVSTTLETQRIELVDECQQRHSVELPTFALRLLGDILSELAMGNTVKVVPI
HAELTTQEGADMLNVSRPHLVRLLDEGVIPHSKTGTHRRVRFTDLMAYKAQRDRASQSSMQALAAQAQELDLGY

Download         Length: 465 bp

>AT49053 NZ_CP009455:3428744-3429208 [Pseudomonas cremoricolorata]
ATGAACACTGCCGATTATTCACAGAGCGTCCTGCCCGATTCAAAAACCATCGGCGCTGCCGTCGAATCGAGCCGCCAGCT
TGCTGCCTTCGTTTCGACTACCTTGGAAACCCAGCGAATCGAGCTGGTTGACGAGTGTCAGCAGCGTCACAGCGTTGAGC
TACCGACCTTCGCGCTTAGGCTGCTGGGCGACATTCTCAGCGAGCTGGCCATGGGCAATACGGTCAAAGTCGTACCCATC
CACGCCGAGCTGACTACCCAGGAGGGCGCCGACATGCTCAACGTATCGCGCCCGCATCTGGTCAGACTGCTTGACGAAGG
GGTGATACCTCACAGCAAGACCGGCACCCACCGTCGCGTTCGCTTCACTGACCTCATGGCCTACAAAGCCCAGCGTGACA
GGGCCAGCCAGTCGTCCATGCAGGCCCTGGCCGCGCAAGCCCAAGAACTCGATCTGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089WQ35

Antitoxin

Source ID Structure
AlphaFold DB A0A089WN43

References