Detailed information of TA system TA049049

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3620918..3621724
• Replicon: chromosome
• Accession: NZ_CP009454
• Organism: Pantoea rwandensis strain ND04

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LH22_RS16590
• Protein ID: WP_038648396.1
• Coordinates: 3620918..3621301 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LH22_RS16595
• Protein ID: WP_038648397.1
• Coordinates: 3621365..3621724 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH22_RS16575	3618859..3619131	+	273	WP_038648388.1	hypothetical protein	-
LH22_RS16580	3619413..3620261	-	849	WP_038648390.1	DUF4942 domain-containing protein	-
LH22_RS16585	3620430..3620921	-	492	WP_038648393.1	hypothetical protein	-
LH22_RS16590	3620918..3621301	-	384	WP_038648396.1	TA system toxin CbtA family protein	Toxin
LH22_RS16595	3621365..3621724	-	360	WP_038648397.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LH22_RS16600	3621756..3621977	-	222	WP_038648399.1	DUF987 domain-containing protein	-
LH22_RS16605	3621987..3622460	-	474	WP_038648401.1	DNA repair protein RadC	-
LH22_RS16610	3622470..3622940	-	471	WP_038648404.1	antirestriction protein	-
LH22_RS20340	3623014..3623236	-	223	Protein_3271	DUF905 family protein	-
LH22_RS16615	3623269..3624090	-	822	WP_038648407.1	DUF945 domain-containing protein	-
LH22_RS16620	3624233..3624586	-	354	WP_038650223.1	hypothetical protein	-
LH22_RS16625	3624640..3625131	-	492	WP_052059435.1	hypothetical protein	-
LH22_RS16630	3625134..3625688	-	555	WP_038648410.1	hypothetical protein	-
LH22_RS20640	3625932..3626087	-	156	Protein_3276	ATP/GTP-binding protein	-
LH22_RS16640	3626216..3626569	-	354	WP_038648413.1	bacteriophage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14488.74 Da
• Isoelectric Point: 10.1751

>T49049 WP_038648396.1 NZ_CP009454:c3621301-3620918 [Pantoea rwandensis]
MQTLPVNPQRAAQTCPAPVEIWQKLLTHLLEQHYGLTLSDTPFSNETTIREHIDAGVSLSDAVNFLVKKYELVRTDRPGF
TIMEQSPFITPIDILRARQATGLMKRRGYRAVSDITRGKMSRLEKKH

Nucleotide

• Length: 384 bp

>T49049 NZ_CP009454:c3621301-3620918 [Pantoea rwandensis]
ATGCAAACCTTACCCGTAAACCCGCAACGGGCGGCACAAACCTGCCCGGCACCTGTTGAAATATGGCAAAAGCTGCTGAC
GCATCTGCTCGAACAACACTATGGACTCACACTCAGTGATACCCCGTTCAGCAATGAAACCACCATCCGTGAGCATATTG
ACGCCGGAGTATCCCTCAGCGATGCGGTGAACTTCCTTGTGAAGAAATATGAACTGGTACGCACTGACCGACCTGGTTTC
ACCATTATGGAGCAGTCACCTTTTATCACCCCAATCGATATTCTCCGCGCCAGACAAGCTACCGGTCTGATGAAGCGTCG
TGGTTATAGAGCAGTGAGTGATATTACTCGTGGCAAAATGAGTCGACTGGAGAAAAAGCATTGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13380.12 Da
• Isoelectric Point: 6.0799

>AT49049 WP_038648397.1 NZ_CP009454:c3621724-3621365 [Pantoea rwandensis]
MKSVALAGIPPEDNPRLQWGLNREVTPRFGARLVQEGNRLHFLADRGGFDGAFSEDEALRLDQAFPLMLKELERKLRSGE
LNPRYQHCVTLNHNGLTCEADTLGSHGYIYITIYPASPE

Nucleotide

• Length: 360 bp

>AT49049 NZ_CP009454:c3621724-3621365 [Pantoea rwandensis]
ATGAAATCTGTTGCCTTAGCCGGTATACCACCGGAGGACAACCCGCGCCTGCAATGGGGATTGAATCGCGAAGTTACACC
CAGATTTGGTGCGCGTCTGGTGCAGGAAGGAAATCGCCTGCATTTTCTGGCTGACCGTGGGGGCTTTGACGGTGCATTCA
GTGAGGATGAGGCGCTGCGGCTTGACCAGGCATTTCCGCTGATGCTCAAAGAGCTTGAACGTAAGCTGCGCTCAGGTGAG
CTCAATCCTCGCTATCAGCATTGCGTTACGTTGAACCACAATGGCCTGACCTGTGAAGCCGACACCCTCGGTTCTCACGG
GTACATTTATATCACCATTTACCCGGCAAGCCCGGAATAA