Detailed information of TA system TA049047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2130798..2131416
• Replicon: chromosome
• Accession: NZ_CP009454
• Organism: Pantoea rwandensis strain ND04

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2M9WH78
• Locus tag: LH22_RS09695
• Protein ID: WP_034824653.1
• Coordinates: 2130798..2130986 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LH22_RS09700
• Protein ID: WP_038646086.1
• Coordinates: 2131006..2131416 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH22_RS09675	2126154..2127491	+	1338	WP_038646081.1	LLM class flavin-dependent oxidoreductase	-
LH22_RS09680	2127663..2128457	-	795	WP_038646083.1	PhnD/SsuA/transferrin family substrate-binding protein	-
LH22_RS09685	2128345..2129394	-	1050	WP_038646085.1	fatty acid desaturase	-
LH22_RS09690	2129612..2130634	+	1023	WP_038650005.1	LLM class flavin-dependent oxidoreductase	-
LH22_RS09695	2130798..2130986	+	189	WP_034824653.1	type II toxin-antitoxin system HicA family toxin	Toxin
LH22_RS09700	2131006..2131416	+	411	WP_038646086.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LH22_RS09705	2131505..2132332	-	828	WP_038646090.1	glycosyltransferase family 8 protein	-
LH22_RS09710	2132353..2133735	-	1383	WP_038646092.1	FAD-binding protein	-
LH22_RS09715	2133809..2134450	-	642	WP_038646094.1	TetR family transcriptional regulator	-
LH22_RS09720	2134662..2135489	+	828	WP_038646097.1	MetQ/NlpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6970.22 Da
• Isoelectric Point: 11.0007

>T49047 WP_034824653.1 NZ_CP009454:2130798-2130986 [Pantoea rwandensis]
MDSRSLMAEIKADGWELIRINGSHHHFVHPTKKGLVTIPHPKKDLPIKTVKSIRKQAGLAVH

Nucleotide

• Length: 189 bp

>T49047 NZ_CP009454:2130798-2130986 [Pantoea rwandensis]
ATGGATAGCAGGTCATTAATGGCTGAGATCAAGGCCGATGGTTGGGAGCTGATTCGGATTAACGGTAGCCATCATCATTT
TGTGCATCCTACCAAGAAAGGTCTGGTAACGATTCCGCACCCCAAAAAAGATCTGCCGATTAAGACGGTAAAAAGCATCC
GTAAACAGGCCGGGCTTGCAGTTCATTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14957.27 Da
• Isoelectric Point: 4.7906

>AT49047 WP_038646086.1 NZ_CP009454:2131006-2131416 [Pantoea rwandensis]
MFYPIAIEAGDESTAFGVTVHDLPGCFSAGDTLEEAVKNAREAIIGHLELMVELEQDIPAVSELKSVMKNPAYTGYVWVL
VEVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTR

Nucleotide

• Length: 411 bp

>AT49047 NZ_CP009454:2131006-2131416 [Pantoea rwandensis]
ATGTTCTATCCGATTGCGATTGAAGCGGGTGATGAAAGCACGGCGTTTGGTGTCACGGTTCATGATTTACCTGGCTGCTT
TTCAGCCGGAGATACGCTGGAAGAAGCGGTAAAAAACGCGAGAGAAGCCATTATTGGTCATCTGGAATTGATGGTTGAGT
TGGAGCAGGATATTCCCGCGGTTTCAGAGTTAAAAAGCGTGATGAAAAATCCCGCCTATACAGGTTATGTTTGGGTGTTG
GTAGAAGTAGATGTCACACGCATTTTAGGTGGTTCAGAGAAGATTAATGTCACTCTGCCGAAGTTGTTAATTGACCGGAT
TGACCGTTGTGTCGCTACCCATCCGGAATTTAAAACCCGTTCAGGTTTTCTGGCTCAGGTGGCACTAGAACGAATTGCCA
AAACTCGCTAG

Structures

Toxin

• AlphaFold DB: A0A2M9WH78