Detailed information of TA system TA049046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2025470..2026101
• Replicon: chromosome
• Accession: NZ_CP009454
• Organism: Pantoea rwandensis strain ND04

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LH22_RS09255
• Protein ID: WP_038645912.1
• Coordinates: 2025470..2025868 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LH22_RS09260
• Protein ID: WP_038645915.1
• Coordinates: 2025868..2026101 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH22_RS09240	2021948..2022655	-	708	WP_038645906.1	two-component system response regulator BaeR	-
LH22_RS09245	2022659..2024050	-	1392	WP_038645908.1	two-component system sensor histidine kinase BaeS	-
LH22_RS09250	2024047..2025453	-	1407	WP_038645910.1	multidrug transporter subunit MdtD	-
LH22_RS09255	2025470..2025868	-	399	WP_038645912.1	type II toxin-antitoxin system VapC family toxin	Toxin
LH22_RS09260	2025868..2026101	-	234	WP_038645915.1	antitoxin	Antitoxin
LH22_RS09265	2026173..2029241	-	3069	WP_038645917.1	multidrug efflux RND transporter permease subunit MdtC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15123.42 Da
• Isoelectric Point: 8.5287

>T49046 WP_038645912.1 NZ_CP009454:c2025868-2025470 [Pantoea rwandensis]
MHRYMLDTNIVIYVIKRRPIEVLERFNANVGRMVISSITLAELVHGAEKSAFPERNLRTVEDFISRLDVLSYDQKAAFHY
GSIRAELEKKGTPIGLNDLHIAAHARSEALTLITNNLREFSRMNGLISENWL

Nucleotide

• Length: 399 bp

>T49046 NZ_CP009454:c2025868-2025470 [Pantoea rwandensis]
ATGCATCGCTACATGCTGGATACCAACATCGTCATCTATGTCATTAAACGCCGCCCGATTGAGGTTCTTGAACGCTTTAA
CGCCAACGTCGGGCGCATGGTCATCTCTTCAATTACGCTTGCTGAACTCGTTCATGGCGCGGAAAAAAGTGCTTTTCCTG
AAAGGAATTTACGCACGGTTGAAGACTTCATTTCGCGTCTGGACGTGCTCAGTTACGATCAAAAGGCAGCATTTCATTAC
GGCTCGATCCGCGCTGAGCTTGAAAAGAAAGGCACACCCATTGGTCTGAATGATTTGCACATCGCTGCACATGCGAGAAG
TGAAGCGCTAACACTCATTACCAACAACCTGCGCGAATTTTCACGGATGAACGGGTTAATCAGCGAAAACTGGCTTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8795.71 Da
• Isoelectric Point: 4.4883

>AT49046 WP_038645915.1 NZ_CP009454:c2026101-2025868 [Pantoea rwandensis]
MSQGTVFTNNRTQNVRIPADMRFPDNVKNVTVRAIGKERILTPIENAWDSFFLGGPSVSDDFMNERASQEQSDREDF

Nucleotide

• Length: 234 bp

>AT49046 NZ_CP009454:c2026101-2025868 [Pantoea rwandensis]
ATGTCTCAAGGTACCGTGTTTACCAATAATCGTACGCAAAACGTGCGTATTCCTGCTGACATGCGCTTTCCAGACAACGT
GAAAAATGTCACGGTGCGTGCGATTGGCAAAGAGCGCATTCTCACACCTATAGAAAACGCCTGGGATAGTTTTTTCCTCG
GTGGCCCCAGCGTAAGTGATGATTTTATGAATGAGCGTGCGTCACAGGAGCAATCTGACAGGGAAGATTTTTAA