Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1230204..1230985 Replicon chromosome
Accession NZ_CP009452
Organism Sphingopyxis sp. 113P3

Toxin (Protein)


Gene name tacT Uniprot ID A0A0M4CX04
Locus tag LH20_RS05880 Protein ID WP_053553420.1
Coordinates 1230204..1230698 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0M5ILD8
Locus tag LH20_RS05885 Protein ID WP_053556121.1
Coordinates 1230695..1230985 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH20_RS05850 1225421..1225831 + 411 WP_053553415.1 type II toxin-antitoxin system VapC family toxin -
LH20_RS05855 1225852..1226520 + 669 WP_053553416.1 secretin and TonB N-terminal domain-containing protein -
LH20_RS22795 1226885..1227079 + 195 Protein_1160 type II toxin-antitoxin system YhaV family toxin -
LH20_RS05860 1227118..1227462 - 345 WP_053556120.1 DUF2958 domain-containing protein -
LH20_RS05865 1227948..1228175 + 228 WP_053553417.1 hypothetical protein -
LH20_RS05870 1228194..1228577 + 384 WP_053553418.1 recombinase family protein -
LH20_RS05875 1228549..1230186 - 1638 WP_053553419.1 recombinase family protein -
LH20_RS05880 1230204..1230698 - 495 WP_053553420.1 GNAT family N-acetyltransferase Toxin
LH20_RS05885 1230695..1230985 - 291 WP_053556121.1 DUF1778 domain-containing protein Antitoxin
LH20_RS05890 1231048..1231281 - 234 WP_053553421.1 hypothetical protein -
LH20_RS05895 1231271..1231486 - 216 WP_053553422.1 AlpA family phage regulatory protein -
LH20_RS05900 1231616..1234591 - 2976 WP_053553423.1 Ti-type conjugative transfer relaxase TraA -
LH20_RS05905 1234774..1235100 + 327 WP_053556122.1 conjugal transfer protein TraD -
LH20_RS05910 1235102..1235368 + 267 WP_053553424.1 conjugal transfer protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-144)

Antitoxin

Vibrio phage ICP1, Orf50

(4-89)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18279.10 Da        Isoelectric Point: 8.1177

>T49039 WP_053553420.1 NZ_CP009452:c1230698-1230204 [Sphingopyxis sp. 113P3]
VTGLRIEKLHRRHAVETFDCGEEALNRFLVRFALPNQMANASQTYLGIAEDDAIVGFYTLVVGEVRHEEAPERLTKGLAR
HPVPVMLLARLGVSEAWQGKRIGAGLLRDAVLRTLQVADIAGVRALVVHAKNDAARSFYERFDFQPSPTDPLHLFALIKD
LKNL

Download         Length: 495 bp

>T49039 NZ_CP009452:c1230698-1230204 [Sphingopyxis sp. 113P3]
GTGACGGGTCTTCGCATCGAGAAGCTGCATCGCCGTCATGCCGTCGAAACATTCGATTGCGGCGAGGAAGCGCTGAATCG
CTTTCTGGTCCGCTTCGCTCTGCCGAACCAGATGGCGAACGCCTCGCAAACCTATTTGGGTATTGCGGAAGACGACGCCA
TCGTGGGTTTCTATACTCTGGTTGTCGGCGAGGTCCGTCACGAGGAAGCCCCCGAGCGGTTGACCAAAGGGTTGGCCCGC
CATCCTGTGCCGGTCATGCTGCTGGCCCGGCTTGGCGTCAGCGAGGCGTGGCAGGGCAAGAGGATCGGCGCGGGGCTGTT
ACGCGATGCCGTTTTGCGGACGCTGCAAGTCGCCGACATTGCCGGTGTCCGGGCGCTCGTGGTTCACGCCAAGAACGATG
CGGCGCGTTCGTTCTATGAGCGGTTCGACTTTCAGCCGTCTCCCACCGACCCGCTGCATCTGTTCGCGCTCATCAAGGAT
TTGAAGAACCTTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10690.16 Da        Isoelectric Point: 7.0169

>AT49039 WP_053556121.1 NZ_CP009452:c1230985-1230695 [Sphingopyxis sp. 113P3]
MTARITRTEKLDLRLTAEAKHTLAAAAQAQRRTLSDFVLESALGRAEEALADRRVFQLPPDKWEAFVAALDAPPRDLPRL
RKLMNEPGVFSDDSSS

Download         Length: 291 bp

>AT49039 NZ_CP009452:c1230985-1230695 [Sphingopyxis sp. 113P3]
ATGACCGCACGCATCACCCGTACCGAAAAGCTCGATCTTCGCCTGACGGCGGAGGCCAAGCATACCCTTGCCGCCGCCGC
GCAGGCGCAACGGCGCACGCTGAGCGACTTCGTGCTCGAAAGCGCGCTGGGCCGGGCCGAGGAAGCCCTTGCCGACCGCC
GCGTGTTCCAGCTTCCACCGGACAAGTGGGAAGCCTTCGTTGCCGCGCTGGACGCGCCCCCGCGTGATCTGCCGCGCCTG
CGCAAGCTGATGAACGAGCCGGGCGTCTTTTCGGACGATAGTTCTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4CX04

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5ILD8

References