Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4414848..4415438 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name pemK Uniprot ID A0A089Q930
Locus tag JT31_RS20380 Protein ID WP_038481446.1
Coordinates 4415106..4415438 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A089Q3U9
Locus tag JT31_RS20375 Protein ID WP_038481443.1
Coordinates 4414848..4415105 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS20360 4410369..4411133 - 765 WP_038481434.1 gamma-glutamyl-gamma-aminobutyrate hydrolase -
JT31_RS20365 4411346..4412764 + 1419 WP_038481437.1 glutamine synthetase family protein -
JT31_RS20370 4413143..4414531 + 1389 WP_038481440.1 APC family permease -
JT31_RS20375 4414848..4415105 + 258 WP_038481443.1 antitoxin Antitoxin
JT31_RS20380 4415106..4415438 + 333 WP_038481446.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JT31_RS20390 4415704..4417485 - 1782 WP_038481447.1 aminopeptidase P family protein -
JT31_RS20395 4417507..4418961 - 1455 WP_038481450.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11939.78 Da        Isoelectric Point: 9.2917

>T49030 WP_038481446.1 NZ_CP009451:4415106-4415438 [Cedecea neteri]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLDDAETKTTGVIRCDQPRTI
DMAARNGKRLERLPEAIVNEVLARLDAILS

Download         Length: 333 bp

>T49030 NZ_CP009451:4415106-4415438 [Cedecea neteri]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCAATTGCCGGTCACGAGCAAAGTGGAAAGCGTCCGGTACTTAT
CGTCTCGAAGGCATCGTTTAACAAGCTGACCCGACTACCCGTTGTTGTTCCTGTCACCAGCGGAGGAAACTTTGCCCGTA
CAGCCGGTTTTACCGTTTCACTGGATGATGCTGAGACCAAAACGACGGGTGTTATTCGCTGTGATCAACCGAGAACGATT
GATATGGCGGCCAGAAATGGTAAGCGTCTGGAACGTCTACCCGAGGCTATTGTGAATGAAGTGCTGGCAAGGCTGGACGC
TATTCTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9432.88 Da        Isoelectric Point: 4.4915

>AT49030 WP_038481443.1 NZ_CP009451:4414848-4415105 [Cedecea neteri]
MHTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDSPAV
GKEIL

Download         Length: 258 bp

>AT49030 NZ_CP009451:4414848-4415105 [Cedecea neteri]
ATGCATACAACTCGCCTTAAAAAGGTCGGCGGCTCTATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGTTGGAGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGACCCGCACGCCGAAATGAGTGAAGAGGATCGAGAATGGATTGATTCGCCTGCGGTA
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089Q930

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q3U9

References