Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3842091..3842709 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag JT31_RS17795 Protein ID WP_008460299.1
Coordinates 3842091..3842306 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag JT31_RS17800 Protein ID WP_008460297.1
Coordinates 3842335..3842709 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS17770 3838247..3840151 + 1905 WP_038480177.1 methyl-accepting chemotaxis protein -
JT31_RS17775 3840276..3840536 + 261 WP_008460319.1 type B 50S ribosomal protein L31 -
JT31_RS17780 3840540..3840680 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JT31_RS17785 3840684..3841160 - 477 WP_038480183.1 YlaC family protein -
JT31_RS17790 3841286..3841837 - 552 WP_038480186.1 maltose O-acetyltransferase -
JT31_RS17795 3842091..3842306 - 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
JT31_RS17800 3842335..3842709 - 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
JT31_RS17805 3843274..3846423 - 3150 WP_038480189.1 multidrug efflux RND transporter permease subunit -
JT31_RS17810 3846446..3847645 - 1200 WP_038480192.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T49027 WP_008460299.1 NZ_CP009451:c3842306-3842091 [Cedecea neteri]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

>T49027 NZ_CP009451:c3842306-3842091 [Cedecea neteri]
ATGACTACCAAACTTACCAAGACCGATTATTTGATGCGTCTGCGACGTTGTCAGACAATTGATACGCTGGAGCGCGTAAT
AGAAAAAAACAAATATGAATTATCAGATAATGAGTTGGCGGTATTTTATTCAGCGGCCGACCATCGTCTTGCTGAACTGA
CGATGAATAAACTGTATGACAAAATCCCACCGTCTGTGTGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT49027 WP_008460297.1 NZ_CP009451:c3842709-3842335 [Cedecea neteri]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp

>AT49027 NZ_CP009451:c3842709-3842335 [Cedecea neteri]
ATGGACGAATACTCACCAAAGCGGCATGATATCGCGCAGCTTAAGTTCCTCTGTGAGAGTCTGTATCACGATTGTCTGAC
CAATCTTGGTGAGAGCAATCATGGATGGGTTAATGATCCGACCTCGGCCATTAATCTACAGCTGAATGAATTGATTGAGC
ACATTGCCGCGTCGGCGCTTAATTATAAGATTAAGTATCCGGACGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTATTTAGCAATTACGGCATTAACGCACAGGATCTGCAGCGGTGGCGTAAATCAGGGAATCGCTT
GTTCAGATGTTTCATCAGCGAGAGCCGCGCTAACCCAGTAAGCCACTCGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References