Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3781879..3782435 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name ccdB Uniprot ID A0A089Q598
Locus tag JT31_RS17515 Protein ID WP_038480036.1
Coordinates 3781879..3782190 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A089Q178
Locus tag JT31_RS17520 Protein ID WP_038480039.1
Coordinates 3782193..3782435 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS17505 3778407..3779873 + 1467 WP_038480030.1 IMP dehydrogenase -
JT31_RS17510 3779941..3781518 + 1578 WP_038480033.1 glutamine-hydrolyzing GMP synthase -
JT31_RS17515 3781879..3782190 - 312 WP_038480036.1 CcdB family protein Toxin
JT31_RS17520 3782193..3782435 - 243 WP_038480039.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JT31_RS17525 3782663..3783868 + 1206 WP_038480042.1 M24 family metallopeptidase -
JT31_RS17530 3783917..3784534 - 618 WP_038480046.1 LysE family transporter -
JT31_RS17535 3784720..3785640 + 921 WP_038480049.1 LysR family transcriptional regulator -
JT31_RS17540 3785634..3786650 - 1017 WP_038480052.1 LD-carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11566.24 Da        Isoelectric Point: 7.2746

>T49026 WP_038480036.1 NZ_CP009451:c3782190-3781879 [Cedecea neteri]
MQFTVYKNTGRPTAYPYLLNVQSNIIGRRNTRVVIPLFPAENYKGPRTDKLTPSINLAGEDFIVMTHELASIPERVLGAE
HCSAAEHENTIKAALNFLFYGIE

Download         Length: 312 bp

>T49026 NZ_CP009451:c3782190-3781879 [Cedecea neteri]
ATGCAATTCACCGTCTACAAAAATACGGGCAGGCCAACGGCTTACCCGTATTTATTGAATGTTCAGAGCAACATCATTGG
GCGCAGAAACACCCGAGTCGTCATTCCTTTATTTCCAGCTGAAAACTATAAAGGGCCACGCACGGACAAACTCACCCCAT
CCATTAACCTGGCCGGTGAGGATTTTATTGTGATGACTCATGAACTCGCGAGCATCCCTGAACGGGTCCTCGGCGCAGAA
CACTGCAGCGCGGCTGAACATGAAAATACAATAAAAGCGGCGCTTAACTTCCTTTTCTATGGCATCGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8976.22 Da        Isoelectric Point: 5.1249

>AT49026 WP_038480039.1 NZ_CP009451:c3782435-3782193 [Cedecea neteri]
MPASASIRVKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF

Download         Length: 243 bp

>AT49026 NZ_CP009451:c3782435-3782193 [Cedecea neteri]
ATGCCCGCATCAGCAAGTATACGAGTGAAAAAAACGGTCACTGTCACACTAGAGCCAGAGCTGATTCAGGAAGCCAGGGC
GGCAGGAATCAACTTGTCACAAACGTTGCGTAATGCTCTAAAGGCCGAAATCAAGGAGATTGAAGCCGCTCGCTGGAAGA
AAGAAAACGAAGCCGCAATCGACTATCTGAATCAGCTCACGGAAGAAAACGGGCTTTTATCCGACACCTACAGGACGTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089Q598

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q178

References