Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3607239..3608036 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name KacT Uniprot ID A0A089Q0R7
Locus tag JT31_RS16760 Protein ID WP_038479633.1
Coordinates 3607512..3608036 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A089Q4R3
Locus tag JT31_RS16755 Protein ID WP_038479630.1
Coordinates 3607239..3607508 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS23890 3602754..3602897 - 144 WP_158399825.1 hypothetical protein -
JT31_RS16725 3603036..3603437 + 402 Protein_3270 type II toxin-antitoxin system MqsA family antitoxin -
JT31_RS16730 3603434..3604366 - 933 WP_038479619.1 LysR family transcriptional regulator -
JT31_RS16735 3604489..3605169 + 681 WP_038479622.1 nitroreductase -
JT31_RS16740 3605219..3605578 - 360 WP_038479625.1 hypothetical protein -
JT31_RS16745 3605728..3606033 - 306 WP_038479628.1 chaperone modulator CbpM -
JT31_RS16750 3606033..3606953 - 921 WP_038483241.1 curved DNA-binding protein -
JT31_RS16755 3607239..3607508 + 270 WP_038479630.1 DUF1778 domain-containing protein Antitoxin
JT31_RS16760 3607512..3608036 + 525 WP_038479633.1 GNAT family N-acetyltransferase Toxin
JT31_RS16765 3608302..3608781 + 480 WP_008458195.1 Rrf2 family transcriptional regulator -
JT31_RS16770 3608885..3612037 - 3153 WP_038479636.1 multidrug efflux RND transporter permease subunit OqxB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(79-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19568.34 Da        Isoelectric Point: 8.4448

>T49025 WP_038479633.1 NZ_CP009451:3607512-3608036 [Cedecea neteri]
VADLMIELFSEQTAYDFRGFDCGEASLNAFLSEHFVRQHNGRFLRGYLLVTKDANPKVLGYYTLSGSCFEKEALPSNTQK
RKIPYANVPSVTLGRLAIHKDLQGQEWGSTLVAHAMKVVYLASQAVGVHGIFVDAINDNAKRFYQKLGFIPLVGKNNNSL
FYPTRSIEKLFEQE

Download         Length: 525 bp

>T49025 NZ_CP009451:3607512-3608036 [Cedecea neteri]
GTGGCAGACCTGATGATTGAATTATTTTCAGAACAAACTGCGTATGATTTTCGCGGCTTCGACTGCGGTGAAGCTTCTCT
GAATGCGTTTCTCTCCGAGCACTTTGTCCGGCAGCATAATGGCCGCTTTTTACGCGGCTATCTTCTTGTGACAAAGGACG
CCAATCCCAAAGTGCTGGGTTACTACACTTTGTCCGGCAGCTGCTTTGAAAAAGAGGCGCTGCCGTCAAACACCCAGAAG
CGAAAAATCCCTTATGCCAATGTCCCCAGCGTGACGCTGGGGCGGCTGGCGATTCACAAAGATCTGCAGGGCCAGGAATG
GGGTTCGACGCTAGTGGCGCATGCGATGAAGGTGGTTTATTTAGCTTCGCAGGCGGTGGGCGTTCATGGGATTTTTGTCG
ATGCCATTAACGACAATGCGAAGCGCTTTTATCAAAAATTAGGGTTTATTCCGCTGGTGGGAAAAAACAACAATTCGCTT
TTTTATCCTACCCGCTCGATTGAGAAATTATTTGAGCAAGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10167.68 Da        Isoelectric Point: 5.8607

>AT49025 WP_038479630.1 NZ_CP009451:3607239-3607508 [Cedecea neteri]
MPALKKQRIDLRLSDDDKSMIEEAAAMSNQTITQFMIACASARAAEVIEQHRRLVLNEASWNLVMDAISNPPEPDDRLKR
ATRRLKDME

Download         Length: 270 bp

>AT49025 NZ_CP009451:3607239-3607508 [Cedecea neteri]
ATGCCAGCTTTAAAAAAACAGCGTATCGATCTTAGATTAAGCGACGACGACAAAAGCATGATCGAAGAGGCTGCGGCAAT
GTCCAACCAGACGATCACTCAGTTTATGATTGCCTGTGCGTCTGCGCGCGCTGCGGAAGTGATCGAGCAACATCGCCGCC
TGGTCCTGAATGAAGCATCATGGAACCTTGTGATGGATGCTATCAGCAACCCGCCTGAACCGGATGACAGGCTCAAACGT
GCAACAAGGCGTCTGAAAGACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089Q0R7

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q4R3

References