Detailed information of TA system TA049023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3239989..3241551
• Replicon: chromosome
• Accession: NZ_CP009451
• Organism: Cedecea neteri strain SSMD04

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A089RHJ6
• Locus tag: JT31_RS15015
• Protein ID: WP_038478722.1
• Coordinates: 3239989..3241290 (-)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JT31_RS15020
• Protein ID: WP_038478725.1
• Coordinates: 3241294..3241551 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT31_RS14985	3236364..3236726	-	363	WP_038478710.1	6-carboxytetrahydropterin synthase QueD	-
JT31_RS23745	3236887..3236988	-	102	WP_144244047.1	integrase core domain-containing protein	-
JT31_RS14990	3236949..3237530	-	582	WP_071842969.1	DDE-type integrase/transposase/recombinase	-
JT31_RS14995	3237563..3237829	-	267	WP_038478713.1	transposase	-
JT31_RS15000	3238029..3239036	-	1008	WP_052049004.1	endonuclease/exonuclease/phosphatase family protein	-
JT31_RS15005	3239107..3239394	-	288	WP_038478716.1	helix-turn-helix domain-containing protein	-
JT31_RS15015	3239989..3241290	-	1302	WP_038478722.1	type II toxin-antitoxin system HipA family toxin	Toxin
JT31_RS15020	3241294..3241551	-	258	WP_038478725.1	helix-turn-helix domain-containing protein	Antitoxin
JT31_RS15025	3241755..3242279	-	525	WP_038478727.1	DUF3455 domain-containing protein	-
JT31_RS15030	3242276..3242803	-	528	WP_052049005.1	superoxide dismutase family protein	-
JT31_RS15035	3243275..3243991	-	717	WP_038478730.1	nicotinamide riboside transporter PnuC	-
JT31_RS15040	3243994..3244740	-	747	WP_038478733.1	nucleoside phosphorylase	-
JT31_RS15045	3244799..3245488	-	690	WP_038483174.1	Crp/Fnr family transcriptional regulator	-
JT31_RS15050	3245715..3246047	+	333	WP_038478736.1	YegP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3237563..3237829	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48274.38 Da
• Isoelectric Point: 6.0099

>T49023 WP_038478722.1 NZ_CP009451:c3241290-3239989 [Cedecea neteri]
MRTQTLTVAMNGDVVGTLYRDGSGAMSFQYVPEWLSEPGARAISLSLPLQHSRIRGKEVFNFFSNLLPDSEAIIARMQAR
FHVETAHPFDLLASVGRDCVGAIQLYPPGSDIPSVMETLAEPLDDSQIETLLDGYQMAPLGMAEGADFRISLAGAQEKTA
LLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIARAFGFPVANAELAVFGQKKVLVVERFDRRWS
RDGWLLRLPQEDFCQALGVAPALKYESHGGPGIADAMKLLLGSRVATQDREIFFKTQILFWMLAAIDGHGKNFSLFIEPE
SSFRMTPLYDVMSAFPIFETVGIPLQKAKMAMALQGKNRQYHFSMIQPRHFISTADHVGFSPKTAFDLMQEMAARTEEVI
ATVTAELPADFPQQISDAIFNGLSHQAARIIRG

Nucleotide

• Length: 1302 bp

>T49023 NZ_CP009451:c3241290-3239989 [Cedecea neteri]
ATGAGAACACAAACTCTGACCGTTGCCATGAACGGCGATGTGGTGGGCACATTGTACCGGGACGGCAGCGGTGCGATGTC
ATTTCAGTACGTACCCGAGTGGCTGTCTGAACCCGGTGCACGCGCCATCTCGTTGTCACTACCCCTCCAGCACAGCCGCA
TAAGAGGAAAAGAAGTTTTCAATTTCTTCAGCAACCTTTTACCCGACTCCGAGGCGATTATTGCCCGGATGCAGGCCCGC
TTCCATGTAGAAACAGCACACCCTTTCGATCTGTTAGCAAGTGTCGGGCGTGACTGCGTGGGTGCCATACAGCTTTACCC
TCCTGGAAGTGACATCCCCTCCGTAATGGAAACGCTGGCAGAGCCGTTGGATGACTCTCAGATAGAAACCCTACTGGATG
GTTACCAGATGGCTCCGTTGGGAATGGCAGAAGGCGCTGATTTTCGTATTTCATTAGCCGGAGCCCAGGAAAAAACAGCC
CTACTCTGGTACCAGGCACGCTGGCAAAGGCCGCAGGGTAGCACCCCGACCAGCCACATTTTCAAACTCCCGATTGGCAG
AATAGAGCAGAACAACATTGACCTGAGTGAAAGCTGCGAAAACGAGTGGCTGTGTTTGCGTATTGCCAGAGCGTTTGGAT
TCCCGGTGGCTAATGCAGAACTTGCCGTATTTGGTCAAAAGAAAGTGCTGGTAGTCGAACGTTTTGACCGAAGATGGTCT
CGCGATGGTTGGCTGCTGCGGCTGCCCCAGGAGGACTTTTGCCAGGCATTGGGCGTTGCCCCGGCCCTGAAATATGAGTC
ACACGGCGGACCGGGCATCGCGGATGCAATGAAATTATTGTTGGGCTCTCGTGTTGCAACGCAGGATCGTGAAATATTCT
TTAAAACACAGATCCTCTTCTGGATGCTGGCCGCTATAGACGGTCACGGGAAGAATTTTAGCTTGTTCATCGAGCCAGAG
TCATCATTTCGTATGACCCCCTTGTACGATGTTATGTCTGCCTTCCCGATCTTTGAAACGGTCGGGATCCCTCTCCAAAA
AGCGAAGATGGCAATGGCATTACAAGGGAAGAATCGGCAGTACCATTTCTCGATGATCCAACCCCGGCATTTCATCAGCA
CTGCCGATCATGTCGGATTTTCTCCGAAAACGGCGTTCGACCTTATGCAGGAAATGGCCGCTCGTACAGAGGAAGTTATC
GCCACAGTTACAGCAGAACTGCCAGCCGACTTTCCCCAACAAATCAGCGATGCTATTTTCAATGGACTATCCCACCAGGC
GGCGCGGATTATCAGAGGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9789.30 Da
• Isoelectric Point: 9.8686

>AT49023 WP_038478725.1 NZ_CP009451:c3241551-3241294 [Cedecea neteri]
MKVTSPTSLAYAVKDQRKINKLTQTKTAEMIGIKQTTVSDFENRPESTKLETLFKILSALDLELHVVKKDTNMDERAAGY
WKKEW

Nucleotide

• Length: 258 bp

>AT49023 NZ_CP009451:c3241551-3241294 [Cedecea neteri]
ATGAAAGTAACGTCACCGACCTCACTGGCTTACGCAGTCAAAGACCAACGAAAAATCAATAAACTGACTCAAACCAAAAC
CGCGGAGATGATTGGAATCAAGCAAACAACTGTCTCTGATTTCGAGAACAGACCAGAGTCCACCAAGCTGGAGACATTAT
TTAAAATCCTCTCAGCACTGGATCTTGAACTGCATGTGGTGAAAAAAGACACAAACATGGATGAGAGAGCAGCCGGGTAC
TGGAAAAAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A089RHJ6