Detailed information of TA system TA049021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 2355607..2356191
• Replicon: chromosome
• Accession: NZ_CP009451
• Organism: Cedecea neteri strain SSMD04

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: JT31_RS23085
• Protein ID: WP_200882460.1
• Coordinates: 2355607..2355864 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: JT31_RS10885
• Protein ID: WP_038476738.1
• Coordinates: 2355916..2356191 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT31_RS10860	2351377..2351682	+	306	WP_038476730.1	hypothetical protein	-
JT31_RS10865	2351779..2353128	+	1350	WP_038476732.1	lysine-sensitive aspartokinase 3	-
JT31_RS10870	2353222..2354154	+	933	WP_038476734.1	ketopantoate/pantoate/pantothenate transporter PanS	-
JT31_RS10875	2354247..2354519	+	273	WP_038483020.1	DUF3811 domain-containing protein	-
JT31_RS10880	2354521..2355399	-	879	WP_038476736.1	23S rRNA pseudouridine(2604) synthase RluF	-
JT31_RS23085	2355607..2355864	+	258	WP_200882460.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JT31_RS10885	2355916..2356191	+	276	WP_038476738.1	putative addiction module antidote protein	Antitoxin
JT31_RS10890	2356220..2357851	-	1632	WP_038476740.1	Na/Pi cotransporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-84)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-89)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9411.24 Da
• Isoelectric Point: 11.6051

>T49021 WP_200882460.1 NZ_CP009451:2355607-2355864 [Cedecea neteri]
MNKLKQTSAFSAWLSLLRDKRAKTVIAARLLRLANGLPGDVQPVGAGISELRIHFGPGYRLYYQQRGKLIILLLCGGSKM
ISTRI

Nucleotide

• Length: 258 bp

>T49021 NZ_CP009451:2355607-2355864 [Cedecea neteri]
ATGAATAAACTCAAACAAACGAGTGCTTTTAGCGCCTGGCTAAGTTTACTTAGAGATAAAAGGGCAAAAACCGTTATTGC
CGCCCGGCTTTTAAGGCTAGCGAATGGTTTACCTGGCGATGTGCAACCCGTTGGGGCAGGCATCAGCGAACTTAGAATCC
ATTTTGGGCCGGGCTATCGCCTTTACTACCAGCAGCGTGGGAAGCTAATCATTTTGCTTCTCTGTGGAGGAAGCAAAATG
ATTAGCACAAGGATATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9660.06 Da
• Isoelectric Point: 4.6895

>AT49021 WP_038476738.1 NZ_CP009451:2355916-2356191 [Cedecea neteri]
MNKLTDYDPASALVDNEEIAFFMADALETGDAAYIAKALGVVARAKGMSQVATETGLSREQLYRSFSAEGNPTLKSTLAV
MKALGITLTVK

Nucleotide

• Length: 276 bp

>AT49021 NZ_CP009451:2355916-2356191 [Cedecea neteri]
ATGAATAAATTAACAGATTACGATCCTGCATCTGCATTGGTCGACAACGAGGAAATTGCTTTTTTCATGGCGGATGCCCT
GGAAACCGGAGATGCAGCCTATATAGCAAAGGCGCTGGGCGTAGTTGCACGGGCAAAAGGGATGTCGCAAGTAGCCACTG
AAACGGGCCTGTCTCGCGAACAGCTGTACCGTTCATTTAGTGCAGAAGGAAACCCAACGCTTAAAAGCACGCTTGCCGTG
ATGAAAGCGCTGGGTATTACCCTTACCGTAAAGTAG