Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2109129..2109724 Replicon chromosome
Accession NZ_CP009451
Organism Cedecea neteri strain SSMD04

Toxin (Protein)


Gene name chpB Uniprot ID A0A089REK3
Locus tag JT31_RS09650 Protein ID WP_038476097.1
Coordinates 2109129..2109479 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A089Q153
Locus tag JT31_RS09655 Protein ID WP_038476100.1
Coordinates 2109473..2109724 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT31_RS09635 2105675..2106673 + 999 WP_038476089.1 class 1 fructose-bisphosphatase -
JT31_RS09640 2106722..2108275 - 1554 WP_038476092.1 Tar ligand binding domain-containing protein -
JT31_RS09645 2108557..2109084 + 528 WP_004857176.1 inorganic diphosphatase -
JT31_RS09650 2109129..2109479 - 351 WP_038476097.1 type II toxin-antitoxin system ChpB family toxin Toxin
JT31_RS09655 2109473..2109724 - 252 WP_038476100.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JT31_RS09660 2109946..2110290 - 345 WP_038476103.1 gamma-glutamylcyclotransferase -
JT31_RS09665 2110293..2114069 - 3777 WP_038476106.1 translocation/assembly module TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12191.89 Da        Isoelectric Point: 4.8002

>T49020 WP_038476097.1 NZ_CP009451:c2109479-2109129 [Cedecea neteri]
MVRRGGFERGDIVLVGFNPAVGREQQGEGRPALVLSTRAFNQTGTALVAPITQGGNYARDAGFAVSLSGCGTETCGVVLI
NQARMVDLECCGAQKRETAPADVVEEVLARLQAIIE

Download         Length: 351 bp

>T49020 NZ_CP009451:c2109479-2109129 [Cedecea neteri]
ATGGTGAGACGAGGGGGTTTTGAAAGGGGAGATATTGTTCTTGTGGGGTTCAATCCCGCCGTTGGCCGGGAGCAACAGGG
GGAAGGCCGTCCTGCTCTTGTGCTTTCAACCCGGGCATTTAACCAGACGGGCACTGCGCTAGTGGCACCTATAACCCAGG
GCGGAAATTACGCAAGGGACGCAGGTTTTGCCGTATCCCTGAGTGGATGCGGGACAGAGACCTGCGGCGTGGTATTAATT
AACCAGGCCAGAATGGTAGATCTTGAATGCTGCGGGGCGCAGAAACGCGAAACAGCGCCGGCAGACGTTGTCGAGGAAGT
TTTAGCCAGACTCCAGGCCATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9190.68 Da        Isoelectric Point: 5.0916

>AT49020 WP_038476100.1 NZ_CP009451:c2109724-2109473 [Cedecea neteri]
MRITIKKWGNSAGMVIPGALMDELGVKIGQSMEAEVIDNQLIMKPARKKYTLDELLAHGDPSAPKISEEDIWGKDNPVGK
EVW

Download         Length: 252 bp

>AT49020 NZ_CP009451:c2109724-2109473 [Cedecea neteri]
ATGCGCATCACCATCAAAAAATGGGGGAACAGTGCTGGTATGGTCATTCCCGGTGCACTAATGGATGAGCTAGGCGTAAA
AATCGGACAAAGCATGGAGGCAGAAGTGATTGATAATCAGCTGATTATGAAACCCGCAAGGAAAAAATATACCCTGGATG
AGCTATTAGCTCATGGCGACCCGTCGGCGCCAAAAATTTCTGAAGAAGACATTTGGGGCAAGGATAACCCGGTCGGGAAA
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089REK3

Antitoxin

Source ID Structure
AlphaFold DB A0A089Q153

References