Detailed information of TA system TA049019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 636382..637016
• Replicon: chromosome
• Accession: NZ_CP009451
• Organism: Cedecea neteri strain SSMD04

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JT31_RS02770
• Protein ID: WP_144244020.1
• Coordinates: 636382..636657 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A089PUA4
• Locus tag: JT31_RS02775
• Protein ID: WP_038473076.1
• Coordinates: 636654..637016 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT31_RS02745	631561..632790	+	1230	WP_038473067.1	peptidase T	-
JT31_RS02750	632942..633535	-	594	WP_038473069.1	tellurite resistance methyltransferase TehB	-
JT31_RS02755	633532..634524	-	993	WP_038473070.1	dicarboxylate transporter/tellurite-resistance protein TehA	-
JT31_RS02760	634638..635564	+	927	WP_038482697.1	acetyltransferase	-
JT31_RS02765	635561..636151	-	591	WP_052048957.1	50S ribosomal protein L7/L12-serine acetyltransferase	-
JT31_RS02770	636382..636657	+	276	WP_144244020.1	type II toxin-antitoxin system HicA family toxin	Toxin
JT31_RS02775	636654..637016	+	363	WP_038473076.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JT31_RS02780	637055..638710	-	1656	WP_038473077.1	glucan biosynthesis protein	-
JT31_RS02785	638964..639740	-	777	WP_038482700.1	transporter substrate-binding domain-containing protein	-
JT31_RS02790	639752..640921	-	1170	WP_038473079.1	pyridoxal phosphate-dependent aminotransferase	-
JT31_RS02795	641040..641891	+	852	WP_038473080.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10287.79 Da
• Isoelectric Point: 10.4537

>T49019 WP_144244020.1 NZ_CP009451:636382-636657 [Cedecea neteri]
MGYGQEYLRNKHRQTLIQIFIKPVPSGVKWQDIERLVLALGGEVNPGRGSRIRFQLNGSIAHFHRPHPSPETDKGAIANL
KEWFESIGVTP

Nucleotide

• Length: 276 bp

>T49019 NZ_CP009451:636382-636657 [Cedecea neteri]
ATGGGATATGGACAGGAATACCTAAGAAACAAACATCGTCAAACGCTAATTCAAATTTTCATCAAGCCCGTTCCCTCCGG
AGTGAAATGGCAGGATATAGAAAGGCTGGTGCTTGCCCTCGGCGGAGAGGTCAACCCCGGCCGCGGTTCACGTATACGCT
TCCAGCTTAACGGCAGCATCGCCCATTTTCATCGCCCCCATCCTTCTCCTGAGACCGATAAAGGGGCCATAGCCAACCTG
AAAGAATGGTTTGAGAGTATCGGAGTCACACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13507.49 Da
• Isoelectric Point: 4.9001

>AT49019 WP_038473076.1 NZ_CP009451:636654-637016 [Cedecea neteri]
MTTAEALPNIMIISGQPALITWVPEINLFRGKFLGLTGYCDFVADSAAGLIREGETALRYYLEDCHSAGIEPFEKEEKMK
TFTLRYPESFGERLSVAAAEQQMSVNSYIIDVLTKHLRNR

Nucleotide

• Length: 363 bp

>AT49019 NZ_CP009451:636654-637016 [Cedecea neteri]
ATGACCACTGCGGAAGCACTGCCAAACATTATGATCATCAGCGGCCAGCCAGCGTTGATCACCTGGGTTCCCGAAATAAA
CCTCTTTCGCGGGAAATTTCTCGGCTTAACCGGATACTGTGACTTCGTCGCCGACAGCGCGGCGGGGCTTATTCGTGAGG
GTGAAACCGCCTTACGGTACTACCTGGAGGACTGCCATTCTGCGGGTATTGAACCTTTTGAAAAAGAAGAGAAAATGAAG
ACGTTCACGCTGCGCTATCCTGAATCCTTTGGCGAACGACTGAGTGTTGCTGCGGCCGAGCAGCAAATGTCGGTTAACAG
TTACATCATTGATGTACTGACAAAACATTTGAGAAATCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A089PUA4