Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4903757..4904377 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name Hha Uniprot ID A0A1S2BLN3
Locus tag LG71_RS22450 Protein ID WP_043085574.1
Coordinates 4904159..4904377 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A089PWG4
Locus tag LG71_RS22445 Protein ID WP_043085573.1
Coordinates 4903757..4904131 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS22435 4898915..4900099 + 1185 WP_043085568.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LG71_RS22440 4900122..4903271 + 3150 WP_043085571.1 multidrug efflux RND transporter permease subunit -
LG71_RS22445 4903757..4904131 + 375 WP_043085573.1 Hha toxicity modulator TomB Antitoxin
LG71_RS22450 4904159..4904377 + 219 WP_043085574.1 hemolysin expression modulator Hha Toxin
LG71_RS22455 4904525..4905079 + 555 WP_043085575.1 maltose O-acetyltransferase -
LG71_RS22460 4905176..4905643 + 468 WP_043085577.1 YlaC family protein -
LG71_RS22465 4905703..4906413 + 711 WP_043085579.1 GNAT family N-acetyltransferase -
LG71_RS22470 4906410..4906550 - 141 WP_043085581.1 type B 50S ribosomal protein L36 -
LG71_RS22475 4906553..4906813 - 261 WP_043085582.1 type B 50S ribosomal protein L31 -
LG71_RS27685 4906891..4907505 - 615 WP_043085584.1 membrane protein -
LG71_RS22485 4907594..4909018 + 1425 WP_043085586.1 PLP-dependent aminotransferase family protein -
LG71_RS22490 4909031..4909246 - 216 WP_043085588.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8587.94 Da        Isoelectric Point: 8.9008

>T49018 WP_043085574.1 NZ_CP009450:4904159-4904377 [Pluralibacter gergoviae]
MSDKALTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T49018 NZ_CP009450:4904159-4904377 [Pluralibacter gergoviae]
ATGTCAGATAAAGCTTTAACGAAAACGGATTATCTGATGCGTTTAAGGCGCTGTCAGAGTATTGATACGCTTGAACGCGT
CATCGAAAAAAATAAGTATGAACTTTCCGATAATGAACTGGCGGTTTTTTACTCAGCAGCCGATCACCGCCTTGCGGAGC
TGACGATGAATAAACTCTATGACAAGATCCCAACGTCGGTATGGAAATTTATACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.20 Da        Isoelectric Point: 4.5729

>AT49018 WP_043085573.1 NZ_CP009450:4903757-4904131 [Pluralibacter gergoviae]
MDEYSPKRHDLAQLKFLCETLYHDCLVNLEENGAGWVNDPTAAINLQLNELIEHIATFALNYKIKYNEDDKLIAQIDEYL
DDTFMLFSNYGINADDLQKWRKSGNRLFRCFINASRANPVSLSC

Download         Length: 375 bp

>AT49018 NZ_CP009450:4903757-4904131 [Pluralibacter gergoviae]
ATGGACGAATATTCGCCAAAAAGACATGATCTCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACGGTGCAGGCTGGGTCAATGACCCTACGGCCGCAATCAACCTTCAACTTAACGAATTGATTGAAC
ACATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACGATAAATTGATCGCACAAATTGATGAGTATCTG
GACGACACCTTTATGCTGTTCAGTAACTATGGCATTAATGCTGATGATTTACAGAAATGGCGAAAATCTGGAAACCGACT
TTTCCGCTGTTTCATAAACGCCAGCCGTGCTAATCCTGTTAGTCTCTCTTGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2BLN3

Antitoxin

Source ID Structure
AlphaFold DB A0A089PWG4

References