Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4582378..4583276 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name - Uniprot ID A0A806NZG6
Locus tag LG71_RS20990 Protein ID WP_043085204.1
Coordinates 4582378..4582836 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A806NZ54
Locus tag LG71_RS20995 Protein ID WP_043085205.1
Coordinates 4582833..4583276 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS20970 4578467..4579783 + 1317 WP_043085197.1 putrescine-ornithine antiporter -
LG71_RS26350 4579867..4580040 + 174 WP_071883418.1 GhoT/OrtT family toxin -
LG71_RS20975 4580063..4580365 + 303 WP_043085200.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS -
LG71_RS20980 4580595..4581479 + 885 WP_043085201.1 EamA family transporter RarD -
LG71_RS20985 4581449..4582354 - 906 WP_043085202.1 alpha/beta hydrolase -
LG71_RS20990 4582378..4582836 - 459 WP_043085204.1 RES family NAD+ phosphorylase Toxin
LG71_RS20995 4582833..4583276 - 444 WP_043085205.1 DUF2384 domain-containing protein Antitoxin
LG71_RS21000 4583331..4584137 - 807 Protein_4242 helix-turn-helix domain-containing protein -
LG71_RS21005 4584237..4585688 + 1452 WP_043085208.1 MFS transporter -
LG71_RS21010 4585757..4587397 - 1641 WP_043085209.1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -
LG71_RS21015 4587426..4587977 - 552 WP_043085211.1 replication initiation negative regulator SeqA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16928.50 Da        Isoelectric Point: 5.1677

>T49017 WP_043085204.1 NZ_CP009450:c4582836-4582378 [Pluralibacter gergoviae]
VIFYRLTKTRYLMSAWSGQGAREAGGRWNSVGTAMVYLSQTASLTMLETLVHLQAPQLLDAFTLLSIEIPDEQIQTLDRQ
RLPETWSGEEAPAQLALIGDEWIASGVSLALRVPSALSPVEDNCLLNPQHPALFDMMAGVKRIPFRFDTRLK

Download         Length: 459 bp

>T49017 NZ_CP009450:c4582836-4582378 [Pluralibacter gergoviae]
GTGATCTTCTACCGGCTGACCAAGACGCGCTATCTGATGAGCGCCTGGTCGGGGCAGGGCGCCCGCGAAGCCGGAGGGCG
CTGGAACAGCGTCGGCACGGCGATGGTCTACCTGTCGCAGACGGCGTCGCTGACGATGCTGGAGACGCTGGTGCACCTCC
AGGCCCCGCAGCTGCTGGACGCCTTCACGCTGCTCAGCATTGAGATCCCTGACGAACAGATCCAGACCCTCGACAGGCAG
CGGCTGCCCGAAACCTGGTCCGGCGAAGAGGCGCCAGCCCAGCTGGCCCTGATCGGCGATGAGTGGATAGCCAGCGGCGT
ATCGCTGGCGCTGCGGGTGCCCAGCGCGCTCTCGCCGGTAGAAGACAACTGTTTACTCAATCCTCAGCATCCTGCACTCT
TCGACATGATGGCCGGCGTGAAGAGAATTCCTTTCCGGTTTGATACGCGCCTTAAATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16478.91 Da        Isoelectric Point: 8.5740

>AT49017 WP_043085205.1 NZ_CP009450:c4583276-4582833 [Pluralibacter gergoviae]
MKLYSPTVTVDKPHDPWRAVGLGTGDGIELMGQISLGLEGDVARRISEWADITPAELRRMSGIPNTTFNRSIKARFTAEQ
SERLVRIVRVLERAVDLFEGDKRAAQKWMSEPNRALGWKAPAEVVFSETGALEVMRLITRLEHGVYS

Download         Length: 444 bp

>AT49017 NZ_CP009450:c4583276-4582833 [Pluralibacter gergoviae]
ATGAAACTCTACTCACCCACCGTTACCGTCGACAAACCTCACGACCCGTGGCGCGCCGTTGGCCTCGGCACCGGCGACGG
TATTGAATTAATGGGGCAGATAAGCCTCGGCCTGGAGGGCGATGTCGCACGGCGCATCTCCGAGTGGGCAGATATCACCC
CGGCGGAGCTGCGCAGGATGTCCGGCATTCCCAATACCACTTTCAACCGCAGCATTAAGGCCCGCTTTACCGCCGAACAG
AGCGAGCGGCTGGTGCGCATTGTGCGCGTGCTGGAGCGCGCGGTAGATCTGTTTGAAGGCGATAAGCGCGCCGCGCAGAA
GTGGATGAGCGAGCCAAACCGCGCGCTGGGCTGGAAAGCGCCCGCAGAGGTCGTCTTCTCTGAAACCGGCGCGCTGGAGG
TGATGCGCCTGATAACCCGGCTGGAGCACGGAGTCTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806NZG6

Antitoxin

Source ID Structure
AlphaFold DB A0A806NZ54

References