49007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2235637..2236306 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag LG71_RS25885 Protein ID WP_071883348.1
Coordinates 2235944..2236306 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag LG71_RS10520 Protein ID WP_043082499.1
Coordinates 2235637..2235954 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS10490 2231749..2232429 + 681 WP_043082493.1 ribonuclease III -
LG71_RS10495 2232426..2233331 + 906 WP_043082494.1 GTPase Era -
LG71_RS10500 2233343..2234068 + 726 WP_043082495.1 DNA repair protein RecO -
LG71_RS10505 2234089..2234820 + 732 WP_043082496.1 pyridoxine 5'-phosphate synthase -
LG71_RS10510 2234820..2235200 + 381 WP_043082497.1 holo-ACP synthase -
LG71_RS10515 2235197..2235457 - 261 WP_043082498.1 YfhL family 4Fe-4S dicluster ferredoxin -
LG71_RS10520 2235637..2235954 - 318 WP_043082499.1 helix-turn-helix domain-containing protein Antitoxin
LG71_RS25885 2235944..2236306 - 363 WP_071883348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG71_RS10530 2236390..2237238 - 849 WP_043082501.1 MurR/RpiR family transcriptional regulator -
LG71_RS10535 2237483..2238118 + 636 WP_043082502.1 phosphatidylglycerophosphatase C -
LG71_RS10540 2238223..2238684 + 462 WP_196300365.1 tRNA adenosine(34) deaminase TadA -
LG71_RS10545 2238681..2240231 - 1551 WP_052097886.1 membrane-bound lytic murein transglycosylase MltF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13417.17 Da        Isoelectric Point: 9.8076

>T49007 WP_071883348.1 NZ_CP009450:c2236306-2235944 [Pluralibacter gergoviae]
ITQKSLYWVGSSRKDLQSLPDDVQDVFGYALYLAQTGSKHSQSKVLKGFGSAGVLEVVEQFFGSTYRAVYTVKFADAVYV
LHAFQKKSSSGIATPKCDLNKIHERLKAAEDHARRAHHER

Download         Length: 363 bp

>T49007 NZ_CP009450:c2236306-2235944 [Pluralibacter gergoviae]
ATAACACAGAAATCTCTCTACTGGGTAGGTAGCAGCAGAAAGGATCTCCAGTCATTACCTGATGATGTGCAGGATGTATT
CGGCTATGCCCTGTATCTCGCTCAAACGGGCAGTAAACATTCTCAGAGCAAAGTGTTGAAAGGTTTTGGTAGCGCCGGAG
TGCTGGAGGTGGTTGAACAATTTTTCGGCAGCACCTATCGCGCTGTCTATACCGTAAAATTTGCCGATGCGGTCTATGTT
TTGCACGCATTTCAGAAGAAGTCCTCATCAGGGATCGCCACACCTAAATGCGATTTGAATAAGATTCATGAACGACTGAA
AGCCGCAGAGGATCATGCCAGGAGAGCGCACCATGAGCGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11384.28 Da        Isoelectric Point: 9.7905

>AT49007 WP_043082499.1 NZ_CP009450:c2235954-2235637 [Pluralibacter gergoviae]
MSDNIEVSSGNVYTDLGDKSAEEMLIKAQLAAAIGQIIKSRGLTQEQAAKLIGLTQPKLSNLLRGQFRGISEAKMLECLT
RLGRDIEIVVSKPRQTPGSLKIIFA

Download         Length: 318 bp

>AT49007 NZ_CP009450:c2235954-2235637 [Pluralibacter gergoviae]
ATGAGCGATAATATCGAAGTAAGCAGCGGTAACGTGTATACCGATCTGGGTGATAAATCTGCTGAAGAGATGCTGATCAA
AGCCCAGCTCGCTGCGGCTATCGGCCAAATCATTAAAAGTCGGGGCCTCACTCAGGAGCAGGCCGCAAAGCTGATTGGCC
TTACGCAACCAAAACTGTCAAACCTGCTGCGCGGTCAATTTCGCGGGATCAGCGAAGCAAAGATGCTGGAGTGTCTTACG
CGGCTGGGGCGCGATATCGAAATCGTGGTCAGCAAACCTCGCCAGACGCCGGGCAGTCTGAAAATAATCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References