Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2119364..2120022 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name ypjF Uniprot ID A0A806ZJD4
Locus tag LG71_RS25835 Protein ID WP_071883340.1
Coordinates 2119364..2119684 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A806NTI2
Locus tag LG71_RS09970 Protein ID WP_043082396.1
Coordinates 2119705..2120022 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS09955 2115252..2115667 - 416 Protein_1998 transposase -
LG71_RS25830 2115853..2117625 + 1773 WP_071883339.1 AAA family ATPase -
LG71_RS09960 2117793..2118833 + 1041 WP_043082394.1 IS481 family transposase -
LG71_RS09965 2118892..2119038 - 147 Protein_2001 integrase -
LG71_RS25835 2119364..2119684 - 321 WP_071883340.1 TA system toxin CbtA family protein Toxin
LG71_RS09970 2119705..2120022 - 318 WP_043082396.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LG71_RS25840 2120041..2120262 - 222 WP_000691995.1 DUF987 domain-containing protein -
LG71_RS09975 2120271..2120747 - 477 WP_043082397.1 RadC family protein -
LG71_RS09980 2120763..2121221 - 459 WP_043082398.1 antirestriction protein -
LG71_RS25845 2121302..2121538 - 237 WP_071883341.1 DUF905 domain-containing protein -
LG71_RS09985 2121616..2122026 - 411 WP_043082399.1 hypothetical protein -
LG71_RS09990 2122116..2122730 - 615 WP_043082400.1 hypothetical protein -
LG71_RS09995 2122727..2123431 - 705 WP_043082401.1 WYL domain-containing protein -
LG71_RS10000 2123633..2124466 - 834 WP_043082402.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2111164..2161845 50681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12032.98 Da        Isoelectric Point: 7.1339

>T49006 WP_071883340.1 NZ_CP009450:c2119684-2119364 [Pluralibacter gergoviae]
MKTLPATTLRAAKPCPSPVIVWQTLLSCLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

>T49006 NZ_CP009450:c2119684-2119364 [Pluralibacter gergoviae]
ATGAAAACTCTACCTGCAACGACTTTGCGGGCGGCTAAACCATGCCCGTCACCAGTGATCGTATGGCAAACACTTCTTTC
ATGCCTGCTGGATCAGCACTATGGCCTGACACTGAATGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCTGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACATA
A

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12053.65 Da        Isoelectric Point: 6.6251

>AT49006 WP_043082396.1 NZ_CP009450:c2120022-2119705 [Pluralibacter gergoviae]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHTHCVILYH
NGFTCEADTLGSCGYVYITVYPTQR

Download         Length: 318 bp

>AT49006 NZ_CP009450:c2120022-2119705 [Pluralibacter gergoviae]
ATGAGTAACATCACATGGGGCCTGCAGCGGGATATCACACCGCGCCTGGGAGCCCGCCTTGTGCAGGAGGGTAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGGAAGCTAGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATACCCACTGCGTCATCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCACCGTTTATCCCACTCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806ZJD4

Antitoxin

Source ID Structure
AlphaFold DB A0A806NTI2

References