Detailed information of TA system TA049005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1964215..1965251
• Replicon: chromosome
• Accession: NZ_CP009450
• Organism: Pluralibacter gergoviae strain FB2

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A806NSW6
• Locus tag: LG71_RS09215
• Protein ID: WP_043082236.1
• Coordinates: 1964676..1965251 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A089PPG5
• Locus tag: LG71_RS09210
• Protein ID: WP_043082235.1
• Coordinates: 1964215..1964676 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG71_RS09195	1960600..1961964	-	1365	WP_043082232.1	LOG family protein	-
LG71_RS09200	1962080..1962925	-	846	WP_043082233.1	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	-
LG71_RS09205	1962995..1963540	+	546	WP_043082234.1	SecY-interacting protein	-
LG71_RS09210	1964215..1964676	+	462	WP_043082235.1	helix-turn-helix domain-containing protein	Antitoxin
LG71_RS09215	1964676..1965251	+	576	WP_043082236.1	PIN domain-containing protein	Toxin
LG71_RS27595	1965375..1965542	+	168	WP_158443164.1	hypothetical protein	-
LG71_RS09220	1965593..1965922	+	330	WP_043082237.1	YqcC family protein	-
LG71_RS09225	1965922..1966701	+	780	WP_043082238.1	tRNA pseudouridine(65) synthase TruC	-
LG71_RS09230	1966721..1967164	+	444	WP_043082239.1	flavodoxin	-
LG71_RS09235	1967286..1970033	-	2748	WP_043082240.1	two-component sensor histidine kinase BarA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21589.94 Da
• Isoelectric Point: 5.3002

>T49005 WP_043082236.1 NZ_CP009450:1964676-1965251 [Pluralibacter gergoviae]
MIHTPYPVVLDACVLYPSLLRDLLLRLGLKGLYQTKWTAAIQDEWQRNLLKNREDITTERIQRTAQLMNAALPDAMVTGY
EKLIDSISLPDPGDRHVVAAAVRCNAEVIVTLNLKDFPGECLTQFDIESLHPDDFISDLFDLNHALALQAAAEQRASMRR
PAKSVEEYLESLLRQGLPMTAKALDRYRAML

Nucleotide

• Length: 576 bp

>T49005 NZ_CP009450:1964676-1965251 [Pluralibacter gergoviae]
ATGATTCACACTCCCTATCCAGTGGTGCTGGATGCCTGCGTACTTTATCCTTCGCTATTGCGGGATTTATTGCTACGTCT
TGGGCTAAAAGGGCTGTATCAAACAAAATGGACAGCTGCTATTCAGGATGAGTGGCAGCGTAATTTACTGAAAAACAGGG
AAGATATTACGACTGAACGCATCCAGCGTACTGCACAGTTAATGAATGCAGCCCTTCCTGATGCGATGGTTACTGGCTAC
GAAAAGCTGATTGATAGTATCAGTTTGCCCGATCCTGGCGATCGTCATGTGGTCGCTGCGGCCGTGCGCTGTAATGCAGA
GGTCATTGTCACGCTCAACCTGAAGGATTTTCCCGGCGAATGTCTGACGCAGTTTGATATCGAGTCGCTTCATCCTGATG
ACTTTATTTCAGATCTTTTTGACTTAAACCACGCGCTGGCGCTACAGGCTGCCGCTGAACAGCGGGCCAGTATGAGAAGA
CCGGCGAAGAGCGTCGAGGAGTACCTTGAATCGCTGCTTCGCCAGGGGCTGCCAATGACAGCCAAAGCGCTGGATAGGTA
TCGGGCAATGCTATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17000.55 Da
• Isoelectric Point: 6.3314

>AT49005 WP_043082235.1 NZ_CP009450:1964215-1964676 [Pluralibacter gergoviae]
MKNAILDSVCLPAPKEIEAAVRGQRELATWLSTRLETQKIAIQDADSISHQIELPTSALILLMTILGELAAGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLENGELPFHKTGRHRRVLFADLMNYKQQRDRLSQQALQELSDLSQDAGLY

Nucleotide

• Length: 462 bp

>AT49005 NZ_CP009450:1964215-1964676 [Pluralibacter gergoviae]
ATGAAAAACGCAATTCTTGATAGCGTATGCTTACCGGCTCCAAAAGAGATCGAGGCTGCCGTTCGCGGACAGCGTGAGCT
TGCAACCTGGTTATCAACCCGGCTCGAAACGCAAAAAATAGCTATTCAGGATGCGGATAGTATTTCGCATCAGATTGAGT
TGCCTACTTCTGCATTGATATTGTTAATGACTATCCTGGGGGAGCTGGCTGCGGGAAACGCGGTGCAGGTCGTGCCTGTG
CACGCTGAGCTGACGACTCAGGAAGCCGCCAATATTCTGAATGTTTCGCGTCCGCATATGGTGAAACTTCTCGAAAATGG
CGAACTGCCCTTTCATAAGACAGGACGCCACCGCCGCGTGCTTTTTGCCGATCTAATGAACTACAAGCAGCAGCGCGATC
GCCTGAGCCAGCAAGCGCTGCAGGAGCTGTCAGACCTTAGTCAGGACGCTGGACTTTACTGA

Structures

Toxin

• AlphaFold DB: A0A806NSW6

Antitoxin

• AlphaFold DB: A0A089PPG5