Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1931645..1932189 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name relE Uniprot ID A0A806NT12
Locus tag LG71_RS09050 Protein ID WP_043082206.1
Coordinates 1931645..1931920 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A806NT14
Locus tag LG71_RS09055 Protein ID WP_043082207.1
Coordinates 1931917..1932189 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS09045 1929801..1931639 + 1839 WP_043082205.1 exodeoxyribonuclease V subunit alpha -
LG71_RS09050 1931645..1931920 - 276 WP_043082206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG71_RS09055 1931917..1932189 - 273 WP_043082207.1 ribbon-helix-helix protein, CopG family Antitoxin
LG71_RS09060 1932307..1933638 - 1332 WP_043082208.1 amino-acid N-acetyltransferase -
LG71_RS09065 1933865..1935118 + 1254 WP_043082209.1 N-acetylmuramoyl-L-alanine amidase AmiC -
LG71_RS09085 1935740..1936843 + 1104 WP_043082210.1 murein transglycosylase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10705.28 Da        Isoelectric Point: 9.8862

>T49004 WP_043082206.1 NZ_CP009450:c1931920-1931645 [Pluralibacter gergoviae]
MRFQWSVPARNDVVRLHQFLADKNEAAAANVVRSLINAPATLLLNPRRGEKIEGFEPREVRRAIIGSYEMHYELQNDVLI
VLRIWHQREDR

Download         Length: 276 bp

>T49004 NZ_CP009450:c1931920-1931645 [Pluralibacter gergoviae]
ATGAGGTTTCAGTGGAGCGTACCAGCCAGAAACGATGTTGTCCGTCTGCACCAGTTTCTGGCCGATAAGAATGAGGCCGC
AGCAGCAAATGTGGTCAGATCTCTGATTAACGCTCCCGCCACCCTACTGCTCAACCCTCGACGGGGAGAGAAAATAGAGG
GGTTTGAACCTCGCGAAGTGCGGCGCGCCATCATCGGCAGCTATGAAATGCATTATGAGCTGCAGAATGATGTATTAATT
GTTCTGCGCATCTGGCACCAGCGCGAGGATCGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10259.65 Da        Isoelectric Point: 4.9001

>AT49004 WP_043082207.1 NZ_CP009450:c1932189-1931917 [Pluralibacter gergoviae]
MADMRTITAPLPIEMAENVDRWAEKHGRTRSWLVREAVGQFLARENERDRLIREALDAVDAGQLISHEDMVAWAESLGTD
KPLPPPEPRK

Download         Length: 273 bp

>AT49004 NZ_CP009450:c1932189-1931917 [Pluralibacter gergoviae]
ATGGCTGATATGCGTACTATCACAGCTCCCCTGCCGATTGAGATGGCTGAAAACGTCGATCGCTGGGCTGAAAAGCACGG
CCGCACCCGCTCATGGTTAGTCAGAGAAGCCGTTGGCCAATTTCTTGCGCGTGAAAATGAGCGCGATCGGCTGATACGCG
AGGCGCTTGATGCCGTCGATGCCGGACAGCTTATTTCTCATGAAGATATGGTCGCCTGGGCCGAATCACTCGGCACAGAT
AAGCCGCTCCCACCGCCGGAGCCGCGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806NT12

Antitoxin

Source ID Structure
AlphaFold DB A0A806NT14

References