Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1845061..1845715 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name cptA Uniprot ID A0A1Y4Y5C6
Locus tag LG71_RS08675 Protein ID WP_043082125.1
Coordinates 1845308..1845715 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2C5WML2
Locus tag LG71_RS08670 Protein ID WP_043082124.1
Coordinates 1845061..1845327 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS08645 1840628..1841782 - 1155 WP_199533730.1 hypothetical protein -
LG71_RS08650 1841803..1842114 - 312 WP_043082121.1 AzlD domain-containing protein -
LG71_RS08655 1842116..1842847 - 732 WP_043082122.1 AzlC family ABC transporter permease -
LG71_RS08660 1842936..1843778 - 843 WP_086499160.1 AraC family transcriptional regulator -
LG71_RS08665 1843830..1844813 - 984 WP_043082123.1 tRNA-modifying protein YgfZ -
LG71_RS08670 1845061..1845327 + 267 WP_043082124.1 FAD assembly factor SdhE Antitoxin
LG71_RS08675 1845308..1845715 + 408 WP_043082125.1 protein YgfX Toxin
LG71_RS08680 1845725..1846246 - 522 WP_043086431.1 flavodoxin FldB -
LG71_RS08685 1846345..1847241 + 897 WP_043082126.1 site-specific tyrosine recombinase XerD -
LG71_RS08690 1847264..1847977 + 714 WP_043082127.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LG71_RS08695 1847983..1849716 + 1734 WP_043082128.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15912.73 Da        Isoelectric Point: 10.9455

>T49003 WP_043082125.1 NZ_CP009450:1845308-1845715 [Pluralibacter gergoviae]
VVLWQSDLRVSWRAQWISLLLHGVVAALVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRINASHGEIKLLTDARLRWQDQ
TWDILGTPWMLESGMMLRLRRLDNRKKSHLWIAADSMDAGEWRDLRRMLQQPSAQ

Download         Length: 408 bp

>T49003 NZ_CP009450:1845308-1845715 [Pluralibacter gergoviae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCGCGCAGTGGATCTCTTTGCTGCTTCATGGCGTAGTCGCCGC
GCTGGTGTTGCTGATGCCCTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGTATTAACGCCAGCCACGGTGAAATCAAGCTGCTCACCGATGCCCGCCTGCGCTGGCAGGATCAG
ACATGGGATATTCTGGGGACGCCGTGGATGCTTGAAAGCGGCATGATGCTGCGGCTGCGGCGGCTGGATAATCGCAAAAA
GAGCCATCTGTGGATCGCGGCTGACAGCATGGACGCGGGAGAGTGGCGGGATCTGCGCCGCATGCTTCAGCAGCCGTCGG
CGCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10499.02 Da        Isoelectric Point: 5.6950

>AT49003 WP_043082124.1 NZ_CP009450:1845061-1845327 [Pluralibacter gergoviae]
MDINNKSRIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFIRLLECDDPDLFNWLMNHGKPADAGLQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT49003 NZ_CP009450:1845061-1845327 [Pluralibacter gergoviae]
ATGGACATCAATAATAAGTCTCGAATCCACTGGGCGTGCCGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTTGAGTATGAATATGACTCCCTGAGTGATGACGACAAGCGGTTGTTTATCCGCCTGCTGGAGTGTGACGACCCCGATC
TTTTCAACTGGCTGATGAATCACGGTAAGCCGGCGGATGCCGGGCTGCAACGGATGGTGCAACTTATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y4Y5C6

Antitoxin

Source ID Structure
AlphaFold DB A0A2C5WML2

References