Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1251057..1251592 Replicon chromosome
Accession NZ_CP009450
Organism Pluralibacter gergoviae strain FB2

Toxin (Protein)


Gene name relE Uniprot ID A0A806NRB4
Locus tag LG71_RS05835 Protein ID WP_043081736.1
Coordinates 1251057..1251344 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A089QYF2
Locus tag LG71_RS05840 Protein ID WP_043081737.1
Coordinates 1251341..1251592 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG71_RS05815 1246635..1247321 - 687 WP_043086362.1 sel1 repeat family protein -
LG71_RS05820 1247574..1249721 - 2148 WP_080732634.1 formate dehydrogenase subunit alpha -
LG71_RS05830 1250019..1250966 + 948 WP_043081735.1 Rpn family recombination-promoting nuclease/putative transposase -
LG71_RS05835 1251057..1251344 - 288 WP_043081736.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG71_RS05840 1251341..1251592 - 252 WP_043081737.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LG71_RS05845 1251683..1252369 - 687 WP_043081738.1 DNA-binding transcriptional regulator CsiR -
LG71_RS05850 1252397..1253797 - 1401 WP_043081739.1 GABA permease -
LG71_RS05855 1253927..1255210 - 1284 WP_043081740.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.00 Da        Isoelectric Point: 10.4201

>T49002 WP_043081736.1 NZ_CP009450:c1251344-1251057 [Pluralibacter gergoviae]
MSYRIKFREDALKEWNRLDKVIQQQFAKKLKKCSEDPHIPAAKLHGMPNCYKIKLRSAGFRLVYQVIDDALIVAVVAVGK
REREDVYARAGDRIR

Download         Length: 288 bp

>T49002 NZ_CP009450:c1251344-1251057 [Pluralibacter gergoviae]
ATGAGCTACAGGATTAAGTTCAGGGAGGATGCCCTGAAAGAATGGAATCGACTGGATAAGGTAATCCAACAGCAATTTGC
CAAAAAACTTAAAAAGTGCAGTGAGGACCCGCATATTCCTGCGGCAAAACTTCATGGAATGCCTAATTGCTACAAAATCA
AGCTGCGCTCTGCCGGTTTCCGGCTGGTGTATCAGGTCATTGATGATGCGCTGATCGTTGCAGTAGTCGCCGTAGGTAAA
AGAGAGCGCGAGGATGTATATGCGCGAGCAGGCGACAGAATCAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9191.54 Da        Isoelectric Point: 4.1546

>AT49002 WP_043081737.1 NZ_CP009450:c1251592-1251341 [Pluralibacter gergoviae]
MPSIILSETTASVSELKSNPMATVSAGEGFPVAILNRNKPAFYCIPAELYERILDALDDQELVRLVNERKDQKLVDVDLD
SLL

Download         Length: 252 bp

>AT49002 NZ_CP009450:c1251592-1251341 [Pluralibacter gergoviae]
ATGCCAAGCATTATATTAAGTGAAACCACCGCCAGCGTCAGCGAGCTGAAAAGTAATCCGATGGCGACAGTCAGCGCAGG
CGAAGGCTTTCCCGTCGCGATTCTCAACCGCAATAAGCCGGCTTTTTACTGCATTCCCGCAGAGTTATACGAGCGCATAC
TCGATGCGCTTGACGACCAGGAGCTGGTCAGGCTGGTCAATGAGCGCAAAGACCAGAAGCTGGTCGATGTGGATCTGGAT
AGCCTGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806NRB4

Antitoxin

Source ID Structure
AlphaFold DB A0A089QYF2

References