Detailed information of TA system TA048998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 37481..38069
• Replicon: chromosome
• Accession: NZ_CP009450
• Organism: Pluralibacter gergoviae strain FB2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LG71_RS00145
• Protein ID: WP_080732625.1
• Coordinates: 37481..37837 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S2BDS7
• Locus tag: LG71_RS00150
• Protein ID: WP_043080699.1
• Coordinates: 37827..38069 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG71_RS00125	32810..33589	-	780	WP_043080695.1	acetolactate decarboxylase	-
LG71_RS00130	33696..34583	+	888	WP_043080696.1	LysR family transcriptional regulator	-
LG71_RS00135	34941..37079	+	2139	WP_043080697.1	anaerobic ribonucleoside-triphosphate reductase	-
LG71_RS00140	37079..37543	+	465	WP_043080698.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LG71_RS00145	37481..37837	-	357	WP_080732625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LG71_RS00150	37827..38069	-	243	WP_043080699.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LG71_RS00155	38517..39188	+	672	WP_043080700.1	EcsC family protein	-
LG71_RS00160	39346..41256	-	1911	WP_043080701.1	BglG family transcription antiterminator	-
LG71_RS00165	41274..42419	-	1146	WP_043080702.1	lactonase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13529.04 Da
• Isoelectric Point: 10.5803

>T48998 WP_080732625.1 NZ_CP009450:c37837-37481 [Pluralibacter gergoviae]
MIYELVFDPRALKEWHKLGDTVRAQFKKKLAEVLCQPRQTSARLCGLPDCYKIKLKSSGYRLVYQVQDEKITVLVIAIGK
RERAAVYKDAGRRVNGLPLAQLMHNLITAPPPNQRRIL

Nucleotide

• Length: 357 bp

>T48998 NZ_CP009450:c37837-37481 [Pluralibacter gergoviae]
ATGATCTATGAACTGGTTTTTGACCCGCGGGCGCTGAAGGAGTGGCATAAGCTGGGCGATACCGTGCGCGCGCAGTTTAA
AAAGAAACTGGCAGAGGTGCTTTGCCAGCCAAGGCAGACCTCAGCCAGGCTGTGCGGGCTGCCCGACTGCTACAAAATTA
AGCTGAAAAGCTCGGGGTATCGGCTGGTTTATCAGGTCCAGGATGAGAAGATAACCGTGCTGGTTATCGCCATCGGCAAA
CGGGAGAGGGCCGCGGTCTATAAGGATGCTGGCAGAAGGGTGAACGGCTTACCGCTAGCGCAGCTTATGCACAACCTGAT
TACTGCTCCCCCGCCAAATCAGCGCCGGATCCTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8964.46 Da
• Isoelectric Point: 5.1086

>AT48998 WP_043080699.1 NZ_CP009450:c38069-37827 [Pluralibacter gergoviae]
MATLNVRLDDKLKEEACTVLAKLNISPTEAVRLLFQYLAENGRMPVKTVTISDSEEALLRTVRERLADPLPGVKVRLDDL

Nucleotide

• Length: 243 bp

>AT48998 NZ_CP009450:c38069-37827 [Pluralibacter gergoviae]
ATGGCGACGCTGAATGTCCGTCTGGACGATAAACTCAAAGAAGAGGCCTGTACCGTGCTGGCAAAACTCAATATCTCACC
CACAGAGGCCGTACGCCTGCTGTTTCAGTATCTCGCCGAAAATGGCCGCATGCCGGTCAAAACGGTGACCATCAGCGACA
GTGAAGAGGCGCTCCTGCGCACCGTCAGAGAGCGGCTGGCCGACCCGCTGCCGGGCGTGAAGGTTCGGCTGGATGATCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2BDS7