Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 15279..15874 Replicon plasmid pBIN_2
Accession NZ_CP009432
Organism Burkholderia glumae LMG 2196 = ATCC 33617

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag KS03_RS00075 Protein ID WP_012734107.1
Coordinates 15279..15629 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag KS03_RS00080 Protein ID WP_012734108.1
Coordinates 15623..15874 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KS03_RS00055 10501..11289 - 789 WP_012734104.1 energy transducer TonB -
KS03_RS00060 11279..13666 - 2388 WP_045678668.1 TonB-dependent receptor -
KS03_RS00065 13968..14432 - 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
KS03_RS30695 14655..14876 - 222 WP_017433768.1 hypothetical protein -
KS03_RS00070 15026..15220 - 195 WP_124837685.1 hypothetical protein -
KS03_RS00075 15279..15629 - 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
KS03_RS00080 15623..15874 - 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KS03_RS00085 16137..16562 - 426 WP_012734109.1 hypothetical protein -
KS03_RS00090 16647..18482 - 1836 WP_045678669.1 site-specific integrase -
KS03_RS00095 18485..18826 - 342 WP_012732710.1 hypothetical protein -
KS03_RS00100 18883..19128 - 246 WP_127913916.1 hypothetical protein -
KS03_RS30700 19125..19367 - 243 WP_124837682.1 hypothetical protein -
KS03_RS00110 19381..19665 - 285 WP_017432347.1 hypothetical protein -
KS03_RS00115 20417..20605 - 189 WP_017432455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144522 144522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T48994 WP_012734107.1 NZ_CP009432:c15629-15279 [Burkholderia glumae LMG 2196 = ATCC 33617]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T48994 NZ_CP009432:c15629-15279 [Burkholderia glumae LMG 2196 = ATCC 33617]
ATGGTGAAGCGGGTCAAGTTCGAGCGAGGCGATATCGTGCGAGTGAGTCTGAGTCCGACGGTCGGCCGTGAGCAGCAAGG
AGATTTTCGTCCCGCGCTTGTGCTCTCTCCGGCGGCGTTTAACGCGCTGGGTGTGGCGCTCGTTGCCCCGATTACCCAGG
GCGGTGAATTCGCCCGCTTTGCAGGTTTTGCGGTTCCGCTCTCCGGTTCGGGGACGGAGACACAGGGAGTGGCACTGGTG
AACATGGTACGCATGCTCGACTTGGAAGGACGCGGCGCACGCAAGATCGAACGCGCGCCCGTCGAAGTGGTAGAGGATGC
CCTGGCCCGTCTTCAAACGATTATTGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT48994 WP_012734108.1 NZ_CP009432:c15874-15623 [Burkholderia glumae LMG 2196 = ATCC 33617]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp

>AT48994 NZ_CP009432:c15874-15623 [Burkholderia glumae LMG 2196 = ATCC 33617]
ATGGAACTAAAGATTCAGAAATGGGGCAATAGCGCGGCGGTGCGTTTGCCGAGCGTATTGCTCGAACAGATCAACGCATC
GGTCGGCGGTTCGCTGAACGCGGACGTGCGGCCGGATGGGGTGCTACTGACCCCGGCCCGGCGGAAGTATGCGCTGGATG
ATCTCGTGGCTCAGTGCGACACGAAGGCGCCTGTTCCGGCCGACATGGCAGCCTGGGGCGAGATCAAGCCGGTGGGACGT
GAAGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References