Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3711602..3712276 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag HR37_RS17610 Protein ID WP_003417282.1
Coordinates 3711602..3712030 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag HR37_RS17615 Protein ID WP_003417286.1
Coordinates 3712034..3712276 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS17585 3707424..3707825 - 402 WP_003417264.1 cytidine deaminase -
HR37_RS17590 3707966..3708400 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
HR37_RS17595 3708397..3708831 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
HR37_RS17600 3708960..3710732 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
HR37_RS17605 3710732..3711523 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
HR37_RS17610 3711602..3712030 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
HR37_RS17615 3712034..3712276 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
HR37_RS17620 3712398..3713012 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
HR37_RS17625 3713009..3713678 - 670 Protein_3444 molybdopterin converting factor subunit 1 -
HR37_RS17630 3713679..3714212 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
HR37_RS20790 3714209..3714535 - 327 WP_003914956.1 4a-hydroxytetrahydrobiopterin dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T48987 WP_003417282.1 NZ_CP009427:c3712030-3711602 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T48987 NZ_CP009427:c3712030-3711602 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT48987 WP_003417286.1 NZ_CP009427:c3712276-3712034 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT48987 NZ_CP009427:c3712276-3712034 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References