Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2940269..2940983 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag HR37_RS13860 Protein ID WP_003413460.1
Coordinates 2940543..2940983 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag HR37_RS13855 Protein ID WP_003413456.1
Coordinates 2940269..2940556 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS13820 2935691..2935936 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HR37_RS13825 2935933..2936337 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
HR37_RS13830 2936554..2937174 + 621 WP_003413441.1 DUF4178 domain-containing protein -
HR37_RS13835 2937185..2937679 + 495 WP_003413444.1 DUF2617 family protein -
HR37_RS13840 2937676..2938107 + 432 WP_003413445.1 DUF4247 domain-containing protein -
HR37_RS13845 2938132..2938590 + 459 WP_003413451.1 DUF350 domain-containing protein -
HR37_RS13850 2938587..2940158 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
HR37_RS13855 2940269..2940556 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
HR37_RS13860 2940543..2940983 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
HR37_RS13865 2941004..2941759 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
HR37_RS13870 2941892..2942488 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
HR37_RS13875 2942496..2943341 - 846 WP_003413466.1 acyl-CoA thioesterase II -
HR37_RS13880 2943370..2944269 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
HR37_RS13885 2944397..2945071 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T48978 WP_003413460.1 NZ_CP009427:2940543-2940983 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T48978 NZ_CP009427:2940543-2940983 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT48978 WP_003413456.1 NZ_CP009427:2940269-2940556 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT48978 NZ_CP009427:2940269-2940556 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References