Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2878804..2879435 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag HR37_RS13585 Protein ID WP_003413174.1
Coordinates 2879058..2879435 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag HR37_RS13580 Protein ID WP_003413167.1
Coordinates 2878804..2879061 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS13550 2874718..2875032 + 315 WP_009937839.1 hypothetical protein -
HR37_RS13555 2875328..2876539 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
HR37_RS13560 2876666..2877325 + 660 WP_003900846.1 LppA family lipoprotein -
HR37_RS13565 2877322..2877984 + 663 WP_003903936.1 hypothetical protein -
HR37_RS13570 2877981..2878259 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
HR37_RS13575 2878352..2878765 + 414 WP_003413164.1 PIN domain nuclease -
HR37_RS13580 2878804..2879061 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
HR37_RS13585 2879058..2879435 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
HR37_RS13590 2879451..2879825 - 375 WP_003413177.1 hypothetical protein -
HR37_RS13595 2879925..2880320 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
HR37_RS13600 2880317..2880562 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
HR37_RS13605 2880973..2881392 - 420 WP_003413190.1 A24 family peptidase -
HR37_RS13610 2881404..2882213 - 810 WP_003413193.1 shikimate dehydrogenase -
HR37_RS13615 2882210..2883463 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
HR37_RS13620 2883456..2883968 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T48976 WP_003413174.1 NZ_CP009427:2879058-2879435 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T48976 NZ_CP009427:2879058-2879435 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT48976 WP_003413167.1 NZ_CP009427:2878804-2879061 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT48976 NZ_CP009427:2878804-2879061 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References