Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2211873..2212417 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag HR37_RS10345 Protein ID WP_003409896.1
Coordinates 2211873..2212169 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag HR37_RS10350 Protein ID WP_003409899.1
Coordinates 2212166..2212417 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS10290 2206906..2207256 - 351 WP_003409871.1 hypothetical protein -
HR37_RS10295 2207267..2208169 - 903 WP_003409874.1 hypothetical protein -
HR37_RS10300 2208190..2208381 - 192 WP_003409876.1 hypothetical protein -
HR37_RS10305 2208382..2208678 - 297 WP_003409877.1 hypothetical protein -
HR37_RS10310 2208918..2209133 + 216 WP_003409878.1 antitoxin -
HR37_RS10315 2209130..2209441 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
HR37_RS22565 2209415..2209936 - 522 WP_003904745.1 hypothetical protein -
HR37_RS10325 2209911..2210288 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
HR37_RS10330 2210330..2210779 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
HR37_RS10335 2210776..2211321 + 546 WP_003409891.1 SecB-like chaperone -
HR37_RS10340 2211210..2211824 - 615 WP_003901296.1 hypothetical protein -
HR37_RS10345 2211873..2212169 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HR37_RS10350 2212166..2212417 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HR37_RS10355 2212404..2212898 + 495 WP_003899099.1 hypothetical protein -
HR37_RS10360 2213058..2213465 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
HR37_RS10365 2213469..2213741 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HR37_RS10370 2213774..2214994 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
HR37_RS10380 2215893..2216690 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T48964 WP_003409896.1 NZ_CP009427:c2212169-2211873 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T48964 NZ_CP009427:c2212169-2211873 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT48964 WP_003409899.1 NZ_CP009427:c2212417-2212166 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT48964 NZ_CP009427:c2212417-2212166 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References