Detailed information of TA system TA048954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1379896..1380584
• Replicon: chromosome
• Accession: NZ_CP009427
• Organism: Mycobacterium tuberculosis strain 96121

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: HR37_RS06565
• Protein ID: WP_003406304.1
• Coordinates: 1380153..1380584 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: HR37_RS06560
• Protein ID: WP_003406302.1
• Coordinates: 1379896..1380156 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HR37_RS06540	1375473..1376297	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
HR37_RS06545	1376302..1377483	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
HR37_RS06550	1377560..1378660	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
HR37_RS06555	1378831..1379820	+	990	WP_003406301.1	malate dehydrogenase	-
HR37_RS06560	1379896..1380156	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
HR37_RS06565	1380153..1380584	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
HR37_RS06570	1380607..1381626	-	1020	WP_017351663.1	PE family protein	-
HR37_RS06575	1381806..1382666	+	861	WP_003903377.1	hypothetical protein	-
HR37_RS06580	1382747..1383577	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
HR37_RS06585	1383634..1383927	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
HR37_RS06590	1383924..1384193	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T48954 WP_003406304.1 NZ_CP009427:1380153-1380584 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T48954 NZ_CP009427:1380153-1380584 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT48954 WP_003406302.1 NZ_CP009427:1379896-1380156 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT48954 NZ_CP009427:1379896-1380156 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6