Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751414..752047 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag HR37_RS03450 Protein ID WP_003403365.1
Coordinates 751414..751797 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag HR37_RS03455 Protein ID WP_003403368.1
Coordinates 751892..752047 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS03425 746706..747242 + 537 WP_003403341.1 50S ribosomal protein L10 -
HR37_RS03430 747279..747671 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
HR37_RS03435 747664..748359 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
HR37_RS03440 748430..749935 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
HR37_RS03445 750016..751026 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
HR37_RS03450 751414..751797 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
HR37_RS03455 751892..752047 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HR37_RS03460 752123..752839 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
HR37_RS03465 753115..753423 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
HR37_RS03470 753410..753655 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
HR37_RS03475 753765..754202 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
HR37_RS03480 754199..754453 - 255 WP_003911263.1 antitoxin VapB7 -
HR37_RS03485 754567..756930 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T48944 WP_003403365.1 NZ_CP009427:c751797-751414 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T48944 NZ_CP009427:c751797-751414 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT48944 WP_003403368.1 NZ_CP009427:c752047-751892 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT48944 NZ_CP009427:c752047-751892 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References