Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 362430..362956 Replicon chromosome
Accession NZ_CP009427
Organism Mycobacterium tuberculosis strain 96121

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag HR37_RS01585 Protein ID WP_003401560.1
Coordinates 362654..362956 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag HR37_RS01580 Protein ID WP_003401555.1
Coordinates 362430..362657 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR37_RS01560 358153..358938 + 786 WP_003401538.1 trans-aconitate 2-methyltransferase -
HR37_RS01565 358927..359730 - 804 WP_003401540.1 hypothetical protein -
HR37_RS01570 359740..361137 - 1398 WP_003401544.1 sulfatase -
HR37_RS01575 361316..362287 + 972 WP_038438485.1 PE family protein -
HR37_RS01580 362430..362657 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
HR37_RS01585 362654..362956 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
HR37_RS01590 363004..363225 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
HR37_RS01595 363222..363647 + 426 WP_003401566.1 PIN domain nuclease -
HR37_RS01600 363783..364415 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
HR37_RS01605 364412..365320 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T48932 WP_003401560.1 NZ_CP009427:362654-362956 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T48932 NZ_CP009427:362654-362956 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT48932 WP_003401555.1 NZ_CP009427:362430-362657 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT48932 NZ_CP009427:362430-362657 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References