Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2184239..2184783 Replicon chromosome
Accession NZ_CP009426
Organism Mycobacterium tuberculosis strain 96075

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag LJ70_RS10205 Protein ID WP_003409896.1
Coordinates 2184239..2184535 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag LJ70_RS10210 Protein ID WP_003409899.1
Coordinates 2184532..2184783 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ70_RS10150 2179272..2179622 - 351 WP_003409871.1 hypothetical protein -
LJ70_RS10155 2179633..2180535 - 903 WP_003899097.1 hypothetical protein -
LJ70_RS10160 2180556..2180747 - 192 WP_003409876.1 hypothetical protein -
LJ70_RS10165 2180748..2181044 - 297 WP_003409877.1 hypothetical protein -
LJ70_RS10170 2181284..2181499 + 216 WP_003409878.1 antitoxin -
LJ70_RS10175 2181496..2181807 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
LJ70_RS22500 2181781..2182302 - 522 WP_003904745.1 hypothetical protein -
LJ70_RS10185 2182277..2182654 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
LJ70_RS10190 2182696..2183145 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
LJ70_RS10195 2183142..2183687 + 546 WP_003409891.1 SecB-like chaperone -
LJ70_RS10200 2183576..2184190 - 615 WP_003901296.1 hypothetical protein -
LJ70_RS10205 2184239..2184535 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJ70_RS10210 2184532..2184783 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LJ70_RS10215 2184770..2185264 + 495 WP_003899099.1 hypothetical protein -
LJ70_RS10220 2185424..2185831 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
LJ70_RS10225 2185835..2186107 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LJ70_RS10230 2186140..2187360 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
LJ70_RS10240 2188259..2189056 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T48903 WP_003409896.1 NZ_CP009426:c2184535-2184239 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T48903 NZ_CP009426:c2184535-2184239 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT48903 WP_003409899.1 NZ_CP009426:c2184783-2184532 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT48903 NZ_CP009426:c2184783-2184532 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References