Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1937942..1938555 Replicon chromosome
Accession NZ_CP009426
Organism Mycobacterium tuberculosis strain 96075

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LJ70_RS09030 Protein ID WP_038438632.1
Coordinates 1937942..1938331 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LJ70_RS09035 Protein ID WP_003408469.1
Coordinates 1938328..1938555 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ70_RS08995 1933571..1934485 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LJ70_RS09000 1934488..1935318 + 831 WP_003408448.1 cyclase family protein -
LJ70_RS09005 1935318..1935668 + 351 WP_003898986.1 cupin domain-containing protein -
LJ70_RS09010 1935721..1936539 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LJ70_RS09015 1936553..1937332 + 780 WP_003408460.1 IclR family transcriptional regulator -
LJ70_RS09030 1937942..1938331 - 390 WP_038438632.1 PIN domain-containing protein Toxin
LJ70_RS09035 1938328..1938555 - 228 WP_003408469.1 antitoxin Antitoxin
LJ70_RS09040 1938773..1940257 + 1485 WP_003408473.1 carboxylase -
LJ70_RS09045 1940254..1941501 + 1248 WP_003408476.1 serine hydrolase -
LJ70_RS09050 1941544..1941963 - 420 WP_003408483.1 hypothetical protein -
LJ70_RS09055 1941953..1942663 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13832.00 Da        Isoelectric Point: 7.0612

>T48899 WP_038438632.1 NZ_CP009426:c1938331-1937942 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTLADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T48899 NZ_CP009426:c1938331-1937942 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCTTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT48899 WP_003408469.1 NZ_CP009426:c1938555-1938328 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT48899 NZ_CP009426:c1938555-1938328 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References