Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1237400..1237968 Replicon chromosome
Accession NZ_CP009426
Organism Mycobacterium tuberculosis strain 96075

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag LJ70_RS05900 Protein ID WP_003405865.1
Coordinates 1237594..1237968 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag LJ70_RS05895 Protein ID WP_003405863.1
Coordinates 1237400..1237597 (+) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ70_RS05875 1233441..1234079 - 639 WP_003898730.1 lipid droplet-associated protein -
LJ70_RS05880 1234169..1235176 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LJ70_RS05885 1235193..1236176 - 984 WP_003898731.1 hypothetical protein -
LJ70_RS05890 1236239..1237312 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
LJ70_RS05895 1237400..1237597 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJ70_RS05900 1237594..1237968 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
LJ70_RS05905 1238171..1238869 + 699 WP_003898733.1 hypothetical protein -
LJ70_RS05910 1238987..1239172 + 186 WP_003901093.1 hypothetical protein -
LJ70_RS05915 1239099..1239374 - 276 WP_003405867.1 hypothetical protein -
LJ70_RS05920 1239617..1239940 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
LJ70_RS05925 1239955..1240665 - 711 WP_003911399.1 hypothetical protein -
LJ70_RS22665 1240687..1240896 + 210 WP_003911400.1 hypothetical protein -
LJ70_RS05935 1240848..1241555 - 708 Protein_1161 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-111)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T48892 WP_003405865.1 NZ_CP009426:1237594-1237968 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T48892 NZ_CP009426:1237594-1237968 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT48892 WP_003405863.1 NZ_CP009426:1237400-1237597 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT48892 NZ_CP009426:1237400-1237597 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TH08


Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References