Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 702739..703382 Replicon chromosome
Accession NZ_CP009426
Organism Mycobacterium tuberculosis strain 96075

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LJ70_RS03165 Protein ID WP_003403187.1
Coordinates 702981..703382 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LJ70_RS03160 Protein ID WP_003403184.1
Coordinates 702739..702984 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ70_RS03125 698019..698549 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LJ70_RS03130 698533..699228 - 696 WP_003918099.1 two-component system response regulator TcrA -
LJ70_RS03135 699351..699662 + 312 WP_003403164.1 hypothetical protein -
LJ70_RS03140 699734..700684 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LJ70_RS03145 700925..701509 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LJ70_RS03150 701511..702221 + 711 Protein_625 transposase -
LJ70_RS03155 702224..702694 + 471 WP_003898523.1 hypothetical protein -
LJ70_RS03160 702739..702984 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJ70_RS03165 702981..703382 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LJ70_RS22050 703770..703937 - 168 WP_077385191.1 DUF3800 domain-containing protein -
LJ70_RS22055 703970..704167 - 198 WP_003403191.1 hypothetical protein -
LJ70_RS03180 704247..705404 - 1158 WP_003898524.1 hypothetical protein -
LJ70_RS03185 705456..705677 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LJ70_RS03190 705819..706424 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T48880 WP_003403187.1 NZ_CP009426:702981-703382 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T48880 NZ_CP009426:702981-703382 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT48880 WP_003403184.1 NZ_CP009426:702739-702984 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT48880 NZ_CP009426:702739-702984 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References