Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1913394..1914182 | Replicon | chromosome |
| Accession | NZ_CP009423 | ||
| Organism | Staphylococcus aureus strain USA300_SUR1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | LG33_RS09855 | Protein ID | WP_031764593.1 |
| Coordinates | 1913721..1914182 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | LG33_RS09850 | Protein ID | WP_000333630.1 |
| Coordinates | 1913394..1913708 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LG33_RS09800 | 1908993..1909472 | - | 480 | WP_000002512.1 | siphovirus Gp157 family protein | - |
| LG33_RS09805 | 1909465..1909701 | - | 237 | WP_000848127.1 | hypothetical protein | - |
| LG33_RS09810 | 1909709..1909969 | - | 261 | WP_000291100.1 | DUF1108 family protein | - |
| LG33_RS09815 | 1910063..1910224 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| LG33_RS09820 | 1910217..1910438 | - | 222 | WP_000977381.1 | hypothetical protein | - |
| LG33_RS09825 | 1910509..1911174 | + | 666 | WP_031764600.1 | hypothetical protein | - |
| LG33_RS09830 | 1911279..1912028 | - | 750 | WP_001148587.1 | phage antirepressor KilAC domain-containing protein | - |
| LG33_RS09835 | 1912030..1912215 | - | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| LG33_RS09840 | 1912789..1912992 | - | 204 | WP_031764597.1 | hypothetical protein | - |
| LG33_RS09845 | 1913006..1913242 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| LG33_RS09850 | 1913394..1913708 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LG33_RS09855 | 1913721..1914182 | + | 462 | WP_031764593.1 | toxin | Toxin |
| LG33_RS09860 | 1914200..1914703 | + | 504 | WP_031764591.1 | hypothetical protein | - |
| LG33_RS09865 | 1914765..1915814 | + | 1050 | WP_031764589.1 | site-specific integrase | - |
| LG33_RS09870 | 1915890..1916909 | - | 1020 | Protein_1854 | YSIRK-type signal peptide-containing protein | - |
| LG33_RS09875 | 1917235..1917546 | - | 312 | WP_000836465.1 | rhodanese-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1873314..1924830 | 51516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18078.46 Da Isoelectric Point: 4.6915
>T48855 WP_031764593.1 NZ_CP009423:1913721-1914182 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKMYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKMYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T48855 NZ_CP009423:1913721-1914182 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCTTTACGTGAAATTGTAGAAGCATACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAGAAGATGTATGGTATTGGTACTC
ACTACGGTGAATACTCAATTACATTTGAACCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCTTTACGTGAAATTGTAGAAGCATACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAGAAGATGTATGGTATTGGTACTC
ACTACGGTGAATACTCAATTACATTTGAACCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT48855 WP_000333630.1 NZ_CP009423:1913394-1913708 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT48855 NZ_CP009423:1913394-1913708 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|