48853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 871839..872316 Replicon chromosome
Accession NZ_CP009423
Organism Staphylococcus aureus strain USA300_SUR1

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag LG33_RS04430 Protein ID WP_000052078.1
Coordinates 871839..872027 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LG33_RS04435 Protein ID WP_001059690.1
Coordinates 872056..872316 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG33_RS04400 867880..868350 + 471 WP_000824472.1 hypothetical protein -
LG33_RS04405 868691..869377 + 687 WP_001548082.1 thermonuclease family protein -
LG33_RS04410 869734..869934 + 201 WP_001059082.1 cold-shock protein -
LG33_RS04415 870430..870648 - 219 WP_000005886.1 hypothetical protein -
LG33_RS04420 870710..870994 - 285 WP_001004395.1 hypothetical protein -
LG33_RS04425 871082..871651 - 570 WP_001106654.1 hypothetical protein -
LG33_RS04430 871839..872027 - 189 WP_000052078.1 hypothetical protein Toxin
LG33_RS04435 872056..872316 - 261 WP_001059690.1 hypothetical protein Antitoxin
LG33_RS04440 872657..872860 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LG33_RS04445 872857..873093 - 237 WP_000368687.1 hypothetical protein -
LG33_RS04450 873318..873899 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
LG33_RS04455 873972..874589 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
LG33_RS04460 874744..875238 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
LG33_RS04465 875637..876059 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
LG33_RS04470 876207..876923 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 866523..897605 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-55)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T48853 WP_000052078.1 NZ_CP009423:c872027-871839 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T48853 NZ_CP009423:c872027-871839 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT48853 WP_001059690.1 NZ_CP009423:c872316-872056 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT48853 NZ_CP009423:c872316-872056 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References