Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 729184..729820 Replicon chromosome
Accession NZ_CP009416
Organism Jeotgalibacillus malaysiensis strain malaysiensis

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JMA_RS04110 Protein ID WP_039807348.1
Coordinates 729470..729820 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0B5AJA0
Locus tag JMA_RS04105 Protein ID WP_039807347.1
Coordinates 729184..729465 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMA_RS04085 725331..725927 - 597 WP_039807344.1 rhomboid family intramembrane serine protease -
JMA_RS04090 725993..726349 + 357 WP_039813227.1 holo-ACP synthase -
JMA_RS04095 726818..727831 + 1014 Protein_786 outer membrane lipoprotein carrier protein LolA -
JMA_RS04100 727881..729029 + 1149 WP_173425103.1 alanine racemase -
JMA_RS04105 729184..729465 + 282 WP_039807347.1 hypothetical protein Antitoxin
JMA_RS04110 729470..729820 + 351 WP_039807348.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMA_RS04115 729935..730762 + 828 WP_039807350.1 STAS domain-containing protein -
JMA_RS04120 730766..731122 + 357 WP_039807352.1 STAS domain-containing protein -
JMA_RS04125 731127..731528 + 402 WP_039807354.1 anti-sigma regulatory factor -
JMA_RS04130 731545..732555 + 1011 WP_039807356.1 PP2C family protein-serine/threonine phosphatase -
JMA_RS04135 732678..733013 + 336 WP_039807358.1 anti-sigma factor antagonist -
JMA_RS04140 733010..733483 + 474 WP_039807360.1 anti-sigma B factor RsbW -
JMA_RS04145 733461..734255 + 795 WP_039807362.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.82 Da        Isoelectric Point: 5.1663

>T48847 WP_039807348.1 NZ_CP009416:729470-729820 [Jeotgalibacillus malaysiensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHVEISSKRNGFERDSVILLEQI
RTLDKQRLTDKITHLDDETMEKVDEALQISLGLVDL

Download         Length: 351 bp

>T48847 NZ_CP009416:729470-729820 [Jeotgalibacillus malaysiensis]
TTGATAGTGAAGCGTGGAGACGTATTTTTTGCTGACCTATCTCCCGTTGTCGGTTCAGAGCAAGGTGGAGTCCGCCCCGT
TCTCATCATCCAAAACGACATCGGAAATCGGTTTAGTCCCACAGTAGTGGTCGCAGCAATTACAGCACAAATTCAAAAAG
CTAAGCTTCCTACCCACGTTGAAATCAGCTCAAAGCGTAATGGCTTTGAACGTGATTCAGTTATTTTGCTGGAACAGATC
AGAACTTTAGACAAACAACGATTAACAGACAAAATAACCCATCTGGATGACGAGACGATGGAAAAGGTAGACGAGGCGCT
TCAGATCAGCCTCGGCTTGGTAGACCTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10575.94 Da        Isoelectric Point: 4.9061

>AT48847 WP_039807347.1 NZ_CP009416:729184-729465 [Jeotgalibacillus malaysiensis]
VSESSATSEILVRLPKQLLTELEAFAEQEELSCSDCIYRATKAYVRDRRRKQTQDAMRRGYMEMAKINLSMASEALQAEY
EADHTIERLVSGG

Download         Length: 282 bp

>AT48847 NZ_CP009416:729184-729465 [Jeotgalibacillus malaysiensis]
GTGTCGGAATCCAGCGCAACATCAGAAATCTTGGTACGATTACCAAAGCAACTGCTTACAGAACTGGAAGCGTTTGCCGA
ACAGGAAGAGTTAAGCTGCAGTGATTGCATTTACCGTGCAACGAAAGCTTATGTCCGTGACAGACGCCGGAAACAAACTC
AAGATGCGATGCGCCGGGGCTATATGGAAATGGCGAAGATCAACTTGTCAATGGCTTCGGAAGCACTTCAGGCAGAGTAC
GAAGCAGACCATACCATTGAACGATTGGTAAGTGGAGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0B5AJA0

References