Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3905790..3906433 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name vagD Uniprot ID A0A8B6KXL5
Locus tag CH47_RS18190 Protein ID WP_005175063.1
Coordinates 3906014..3906433 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A8B6KZB3
Locus tag CH47_RS18185 Protein ID WP_005175070.1
Coordinates 3905790..3906017 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS18160 3900973..3902136 + 1164 WP_005175073.1 mannitol-1-phosphate 5-dehydrogenase -
CH47_RS18165 3902251..3902805 + 555 WP_005161972.1 MltR family transcriptional regulator -
CH47_RS18170 3902802..3903413 - 612 WP_005175072.1 LysE family translocator -
CH47_RS18175 3903558..3905039 + 1482 WP_032903210.1 PLP-dependent aminotransferase family protein -
CH47_RS18180 3905132..3905488 + 357 WP_005161962.1 YibL family ribosome-associated protein -
CH47_RS18185 3905790..3906017 + 228 WP_005175070.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CH47_RS18190 3906014..3906433 + 420 WP_005175063.1 type II toxin-antitoxin system VapC family toxin Toxin
CH47_RS18195 3906458..3907132 - 675 WP_005175061.1 6-N-hydroxylaminopurine resistance protein -
CH47_RS18200 3907211..3909160 - 1950 WP_005175054.1 methyl-accepting chemotaxis protein -
CH47_RS18205 3909518..3910141 - 624 WP_005175051.1 superoxide dismutase [Mn] -
CH47_RS18210 3910268..3911122 - 855 WP_050137225.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15394.93 Da        Isoelectric Point: 9.0693

>T48843 WP_005175063.1 NZ_CP009367:3906014-3906433 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPNHNYLVDESVKRLDAILPWDT
AAVNATTNIKVELAKQGTSIGGNDAAIAGHAISVGAILVTNNIGEFERVKKLRIEDRTL

Download         Length: 420 bp

>T48843 NZ_CP009367:3906014-3906433 [Yersinia enterocolitica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ACTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTCTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAATCATAATTATTTAGTTGATGAATCTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTAATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACATCAATTGGTGGAAATGATGCCGCCAT
AGCAGGGCATGCTATTTCTGTTGGCGCAATATTAGTCACTAATAATATTGGAGAATTTGAAAGAGTCAAAAAGTTGAGAA
TAGAAGACCGGACTCTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8800.94 Da        Isoelectric Point: 4.1971

>AT48843 WP_005175070.1 NZ_CP009367:3905790-3906017 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGLTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT48843 NZ_CP009367:3905790-3906017 [Yersinia enterocolitica]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCTTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGGCGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6KXL5

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6KZB3

References