Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3222883..3223384 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name relE Uniprot ID A0A8B6L013
Locus tag CH47_RS15125 Protein ID WP_005175262.1
Coordinates 3222883..3223140 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A1JJ37
Locus tag CH47_RS15130 Protein ID WP_005175264.1
Coordinates 3223130..3223384 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS15095 3218489..3219074 - 586 Protein_2866 HEAT repeat domain-containing protein -
CH47_RS15100 3219124..3220431 - 1308 WP_005175249.1 cytosine permease -
CH47_RS15105 3220468..3221157 - 690 WP_005175259.1 PAS and helix-turn-helix domain-containing protein -
CH47_RS15110 3221183..3221593 - 411 WP_005159173.1 GNAT family N-acetyltransferase -
CH47_RS15115 3221954..3222316 - 363 Protein_2870 hypothetical protein -
CH47_RS15120 3222321..3222671 + 351 Protein_2871 transcriptional regulator -
CH47_RS15125 3222883..3223140 - 258 WP_005175262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH47_RS15130 3223130..3223384 - 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CH47_RS15140 3224314..3224595 + 282 WP_005175267.1 BrnT family toxin -
CH47_RS15145 3224582..3224896 + 315 WP_005175269.1 BrnA antitoxin family protein -
CH47_RS15150 3225031..3226290 - 1260 Protein_2876 integrase arm-type DNA-binding domain-containing protein -
CH47_RS15160 3226961..3228031 - 1071 WP_005175277.1 LPS export ABC transporter permease LptG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10105.79 Da        Isoelectric Point: 8.0296

>T48842 WP_005175262.1 NZ_CP009367:c3223140-3222883 [Yersinia enterocolitica]
MTFNIDFDERALKEWHKLDKAIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KLEDE

Download         Length: 258 bp

>T48842 NZ_CP009367:c3223140-3222883 [Yersinia enterocolitica]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAGCTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGCTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTGGATCGTTGCTGTTGGT
AAACTGGAAGATGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9680.07 Da        Isoelectric Point: 4.8283

>AT48842 WP_005175264.1 NZ_CP009367:c3223384-3223130 [Yersinia enterocolitica]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL

Download         Length: 255 bp

>AT48842 NZ_CP009367:c3223384-3223130 [Yersinia enterocolitica]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGTCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCATTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATCTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCCAAGCGTATCAGGGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6L013

Antitoxin

Source ID Structure
AlphaFold DB A1JJ37

References