Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2649650..2650267 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH47_RS12745 Protein ID WP_002208622.1
Coordinates 2650064..2650267 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6TU35
Locus tag CH47_RS12740 Protein ID WP_005167670.1
Coordinates 2649650..2650018 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS12710 2645317..2645577 + 261 WP_005163438.1 type B 50S ribosomal protein L31 -
CH47_RS12715 2645592..2645735 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH47_RS12720 2645862..2646740 - 879 WP_005167678.1 metal ABC transporter substrate-binding protein -
CH47_RS12725 2646786..2647643 - 858 WP_005167676.1 metal ABC transporter permease -
CH47_RS12730 2647640..2648368 - 729 WP_032902542.1 ABC transporter ATP-binding protein -
CH47_RS12735 2649139..2649492 + 354 WP_005167672.1 hypothetical protein -
CH47_RS12740 2649650..2650018 + 369 WP_005167670.1 Hha toxicity modulator TomB Antitoxin
CH47_RS12745 2650064..2650267 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH47_RS12750 2651113..2651418 + 306 WP_032901164.1 MGMT family protein -
CH47_RS12755 2651470..2652000 - 531 WP_005167665.1 lipoprotein -
CH47_RS12760 2652258..2653121 + 864 WP_005167662.1 acyl-CoA thioesterase II -
CH47_RS12765 2653421..2654710 - 1290 WP_005167660.1 ammonium transporter AmtB -
CH47_RS12770 2654750..2655088 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T48841 WP_002208622.1 NZ_CP009367:2650064-2650267 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T48841 NZ_CP009367:2650064-2650267 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14134.86 Da        Isoelectric Point: 4.4085

>AT48841 WP_005167670.1 NZ_CP009367:2649650-2650018 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT48841 NZ_CP009367:2649650-2650018 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6L1C1

References