Detailed information of TA system TA048840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1620524..1621484
• Replicon: chromosome
• Accession: NZ_CP009367
• Organism: Yersinia enterocolitica strain WA

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9F4G8
• Locus tag: CH47_RS08025
• Protein ID: WP_005169553.1
• Coordinates: 1621026..1621484 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9F4G7
• Locus tag: CH47_RS08020
• Protein ID: WP_005169556.1
• Coordinates: 1620524..1620970 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH47_RS08000	1616173..1616880	+	708	WP_005169573.1	murein tripeptide amidase MpaA	-
CH47_RS08005	1616877..1617848	-	972	WP_005169570.1	L-Ala-D/L-Glu epimerase	-
CH47_RS08010	1618001..1618504	+	504	WP_005161000.1	thiol peroxidase	-
CH47_RS08015	1618627..1620204	-	1578	WP_005169566.1	transcriptional regulator TyrR	-
CH47_RS08020	1620524..1620970	+	447	WP_005169556.1	DUF2384 domain-containing protein	Antitoxin
CH47_RS08025	1621026..1621484	+	459	WP_005169553.1	RES family NAD+ phosphorylase	Toxin
CH47_RS08030	1621487..1622551	-	1065	WP_005169550.1	YcjF family protein	-
CH47_RS08035	1622548..1623945	-	1398	WP_005169547.1	YcjX family protein	-
CH47_RS08040	1623926..1624165	-	240	WP_005169543.1	phage shock protein PspD	-
CH47_RS08045	1624211..1624630	-	420	WP_005169539.1	envelope stress response membrane protein PspC	-
CH47_RS08050	1624630..1624857	-	228	WP_005161022.1	envelope stress response membrane protein PspB	-
CH47_RS08055	1625019..1625684	-	666	WP_005169534.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17222.60 Da
• Isoelectric Point: 4.8675

>T48840 WP_005169553.1 NZ_CP009367:1621026-1621484 [Yersinia enterocolitica]
MMLYRIVMRRYLASTWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQTCLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T48840 NZ_CP009367:1621026-1621484 [Yersinia enterocolitica]
ATGATGCTCTACCGCATTGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAACCTATGGTGGGCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACGTTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGCAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAGTCAGAATC
ATCACTTGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTACTGCTCAATCCTCGGCACAAAAGCTTTC
AAACCTGCTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16336.80 Da
• Isoelectric Point: 9.8753

>AT48840 WP_005169556.1 NZ_CP009367:1620524-1620970 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT48840 NZ_CP009367:1620524-1620970 [Yersinia enterocolitica]
ATGAGAGCGTATCACCCCACTCCAGCGACCAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
GGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATCCATCTATGGGCATCTATCCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGCAGCTTGACTCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGTTTCGTTCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCAGATTCCTTGCTGGAGACCGAAACCGGTGCATTGG
AAGTCTGTGATTTGATTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A8B6KS49

Antitoxin

• AlphaFold DB: A0A8B6KRT3