Detailed information of TA system TA048839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1407266..1407903
• Replicon: chromosome
• Accession: NZ_CP009367
• Organism: Yersinia enterocolitica strain WA

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CH47_RS07090
• Protein ID: WP_005170069.1
• Coordinates: 1407266..1407670 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0T9QJI8
• Locus tag: CH47_RS07095
• Protein ID: WP_005170066.1
• Coordinates: 1407670..1407903 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH47_RS07070	1403812..1404108	+	297	WP_002211830.1	integration host factor subunit alpha	-
CH47_RS07080	1404329..1405130	+	802	Protein_1303	IS3 family transposase	-
CH47_RS07085	1405390..1406274	-	885	WP_072075853.1	Rpn family recombination-promoting nuclease/putative transposase	-
CH47_RS23090	1406480..1406656	-	177	WP_005170072.1	hypothetical protein	-
CH47_RS07090	1407266..1407670	-	405	WP_005170069.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CH47_RS07095	1407670..1407903	-	234	WP_005170066.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CH47_RS07100	1408385..1408999	-	615	WP_005170056.1	tail fiber assembly protein	-
CH47_RS07110	1408999..1410076	-	1078	Protein_1309	phage tail protein	-
CH47_RS07115	1410347..1410643	-	297	WP_005170044.1	NINE protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14907.16 Da
• Isoelectric Point: 7.4667

>T48839 WP_005170069.1 NZ_CP009367:c1407670-1407266 [Yersinia enterocolitica]
MHKYMLDTNIVIYVIKRRPIEVLGRFNANAGRMVISSITLAELLHGVEKSAAPERNLSVVEDFVSRLTVLDYDDKAAIHY
GSIRASLEQKGTPIGVNDLHIAGHARSTGLILVTNNRKEFDRVPGLIVDNWLGE

Nucleotide

• Length: 405 bp

>T48839 NZ_CP009367:c1407670-1407266 [Yersinia enterocolitica]
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAACGCCGGCCTATAGAAGTGTTAGGTCGGTTTAA
CGCTAATGCGGGCAGAATGGTTATTTCTTCCATCACACTGGCTGAGTTATTGCATGGCGTAGAGAAAAGCGCGGCACCTG
AACGCAATTTAAGTGTTGTAGAGGATTTTGTTTCACGTCTTACTGTATTGGATTATGACGATAAAGCCGCAATTCACTAT
GGTTCTATACGTGCGAGTCTGGAGCAAAAAGGCACACCCATCGGTGTTAATGATTTGCATATCGCAGGTCATGCCAGAAG
CACCGGATTGATATTAGTGACCAATAATCGCAAAGAATTTGATCGTGTGCCTGGACTGATTGTCGACAACTGGCTAGGAG
AATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8978.95 Da
• Isoelectric Point: 5.0351

>AT48839 WP_005170066.1 NZ_CP009367:c1407903-1407670 [Yersinia enterocolitica]
MSQGTIFTNNRTQNVRLPVDMRFPENVKSVTVRAVGNERILSPVENSWDSFFFSSPRVSDDFLTERAEQHQSERELF

Nucleotide

• Length: 234 bp

>AT48839 NZ_CP009367:c1407903-1407670 [Yersinia enterocolitica]
ATGTCACAGGGCACCATTTTTACGAACAACCGTACTCAAAACGTGCGTTTACCGGTGGATATGCGCTTTCCAGAGAATGT
TAAATCAGTGACTGTGAGAGCTGTAGGGAATGAGCGTATCTTGTCACCCGTTGAAAACTCTTGGGATAGCTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACCGAACGCGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0T9QJI8