Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 596632..597167 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name relE Uniprot ID A0A8B6KW45
Locus tag CH47_RS03260 Protein ID WP_005172322.1
Coordinates 596880..597167 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B6KUS5
Locus tag CH47_RS03255 Protein ID WP_005172325.1
Coordinates 596632..596883 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS03230 591939..592442 + 504 WP_005172332.1 ferredoxin-type protein NapF -
CH47_RS03235 592432..592698 + 267 WP_005165688.1 chaperone NapD -
CH47_RS03240 592695..595190 + 2496 WP_042593212.1 nitrate reductase catalytic subunit NapA -
CH47_RS03245 595261..595728 + 468 WP_005165692.1 nitrate reductase cytochrome c-type subunit -
CH47_RS03250 595756..596355 + 600 WP_005172326.1 cytochrome c-type protein NapC -
CH47_RS03255 596632..596883 + 252 WP_005172325.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CH47_RS03260 596880..597167 + 288 WP_005172322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH47_RS03265 597196..597771 + 576 WP_005172319.1 GDP-mannose pyrophosphatase NudK -
CH47_RS03270 597992..600271 + 2280 WP_005172316.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
CH47_RS03275 601071..601754 + 684 WP_032902930.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11076.06 Da        Isoelectric Point: 10.6907

>T48829 WP_005172322.1 NZ_CP009367:596880-597167 [Yersinia enterocolitica]
MTYIVKFRDEALKEWHKLDKTIQQQFAKKLKKCSENPHIESARLRGIKNGYKIKLRASGFRLVYEVIDGILVVAVVAVGK
RERSEVYKLASDRLR

Download         Length: 288 bp

>T48829 NZ_CP009367:596880-597167 [Yersinia enterocolitica]
ATGACTTATATCGTTAAATTCAGAGACGAAGCGCTAAAGGAATGGCACAAACTGGATAAGACGATACAACAGCAGTTTGC
CAAGAAATTAAAAAAATGCAGTGAAAATCCCCATATTGAAAGTGCCAGACTGCGGGGGATCAAGAATGGTTACAAAATTA
AATTACGTGCCTCTGGTTTTCGCCTCGTGTATGAAGTTATTGATGGTATTTTGGTAGTTGCAGTGGTTGCGGTAGGGAAA
AGAGAACGTAGTGAGGTTTATAAACTGGCCAGTGATAGATTACGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.53 Da        Isoelectric Point: 4.3287

>AT48829 WP_005172325.1 NZ_CP009367:596632-596883 [Yersinia enterocolitica]
MPSVILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPVFYCVPAELYEQIMEALDDHELARLVNERRNQPLHDIDLD
SYL

Download         Length: 252 bp

>AT48829 NZ_CP009367:596632-596883 [Yersinia enterocolitica]
ATGCCAAGTGTTATTTTGACAGATACCAGCGCGAGCGTAAGTGAACTGAAGAAAAATCCCATGGCGACAGTGAATGCTGG
GGCAGGTTTCCCTGTTGCTATTCTGAACCGTAATCAACCTGTATTTTATTGTGTGCCCGCTGAACTCTATGAGCAAATAA
TGGAAGCGCTTGATGATCATGAATTAGCCAGGCTGGTGAATGAACGTCGTAATCAACCACTTCATGATATTGATTTGGAT
AGCTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6KW45

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6KUS5

References