Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 170220..170892 Replicon chromosome
Accession NZ_CP009367
Organism Yersinia enterocolitica strain WA

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag CH47_RS01235 Protein ID WP_005166047.1
Coordinates 170467..170892 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag CH47_RS01230 Protein ID WP_004390965.1
Coordinates 170220..170486 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH47_RS01210 166640..167077 + 438 WP_005173494.1 lipocalin-like domain-containing protein -
CH47_RS21335 167116..167250 + 135 Protein_156 SDR family oxidoreductase -
CH47_RS01215 167263..167865 - 603 WP_005173488.1 HD domain-containing protein -
CH47_RS01220 168096..168779 + 684 WP_005173485.1 hemolysin III family protein -
CH47_RS01225 168833..169825 - 993 WP_005173484.1 tRNA-modifying protein YgfZ -
CH47_RS01230 170220..170486 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
CH47_RS01235 170467..170892 + 426 WP_005166047.1 protein YgfX Toxin
CH47_RS01240 170892..171590 + 699 WP_005173478.1 two-component system response regulator CreB -
CH47_RS01245 171601..173028 + 1428 WP_032909123.1 two-component system sensor histidine kinase CreC -
CH47_RS01250 173120..174541 + 1422 WP_005173463.1 cell envelope integrity protein CreD -
CH47_RS01255 174600..175118 - 519 WP_005173454.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T48828 WP_005166047.1 NZ_CP009367:170467-170892 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T48828 NZ_CP009367:170467-170892 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTGACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTATTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT48828 WP_004390965.1 NZ_CP009367:170220-170486 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT48828 NZ_CP009367:170220-170486 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGCTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References