Detailed information of TA system TA048827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4612631..4613253
• Replicon: chromosome
• Accession: NZ_CP009365
• Organism: Pseudomonas soli strain SJ10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1H9I4P8
• Locus tag: O165_RS21240
• Protein ID: WP_023630583.1
• Coordinates: 4613062..4613253 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: O165_RS21235
• Protein ID: WP_023630582.1
• Coordinates: 4612631..4613044 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O165_RS21215	4607806..4608018	+	213	WP_023629983.1	DUF3079 domain-containing protein	-
O165_RS21220	4608095..4610389	-	2295	WP_031314879.1	TonB-dependent siderophore receptor	-
O165_RS21225	4610530..4611249	+	720	WP_023629985.1	response regulator	-
O165_RS21230	4611251..4612630	+	1380	WP_038706992.1	HAMP domain-containing protein	-
O165_RS21235	4612631..4613044	-	414	WP_023630582.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
O165_RS21240	4613062..4613253	-	192	WP_023630583.1	type II toxin-antitoxin system HicA family toxin	Toxin
O165_RS21245	4613433..4613978	-	546	WP_023630584.1	HDIG domain-containing protein	-
O165_RS21250	4614062..4615084	-	1023	WP_038706993.1	putative 2-aminoethylphosphonate ABC transporter substrate-binding protein	-
O165_RS21255	4615115..4616839	-	1725	WP_038706994.1	putative 2-aminoethylphosphonate ABC transporter permease subunit	-
O165_RS21260	4616841..4617899	-	1059	WP_038706995.1	putative 2-aminoethylphosphonate ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7077.22 Da
• Isoelectric Point: 10.2291

>T48827 WP_023630583.1 NZ_CP009365:c4613253-4613062 [Pseudomonas soli]
MNSREMIAVIEADGWYLVRSKGSHHHFKHPEKAGLVTIPHPRKDLLPATAASILRQARICYAS

Nucleotide

• Length: 192 bp

>T48827 NZ_CP009365:c4613253-4613062 [Pseudomonas soli]
ATGAACAGCCGTGAAATGATTGCTGTGATCGAGGCGGATGGCTGGTATCTGGTGCGCTCCAAAGGCAGCCACCATCACTT
CAAGCATCCTGAAAAAGCCGGGCTGGTCACCATCCCGCATCCCAGGAAAGACCTGCTGCCCGCGACTGCGGCCAGCATCC
TGCGCCAGGCACGCATCTGCTACGCCAGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14890.91 Da
• Isoelectric Point: 4.7269

>AT48827 WP_023630582.1 NZ_CP009365:c4613044-4612631 [Pseudomonas soli]
MLFPIAILSGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPRASKVGVHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDGK

Nucleotide

• Length: 414 bp

>AT48827 NZ_CP009365:c4613044-4612631 [Pseudomonas soli]
ATGTTGTTCCCTATTGCGATCCTTTCCGGTGACGACCAGCACGCCTGGGGCGTGGAAGTCCCGGATATCCCTGGCTGCTT
TTCGGCGGGCGAAGACCTCGACAACGCCATCGCCATGGCGCGTGAAGCGATCGAAGGCCACCTCGAACTCCTGGCCCAGG
ACCAGCAGGAAATCCCCAGGGCCAGCAAGGTCGGCGTGCATGCGGCCAACCCCGCCTATGCCGGCTGCACCTGGGCACTG
ATCGATATCGACATCACCCGCTACCTGGGCAAGGCCGAGAAGCTCAACATCACCTTGCCGGCGTACCTGCTCACCCGCAT
CGACAGCTACGTACAGAACCACCCGGAGCACAAGAGCCGTTCGGGCTTCCTGGCCGAGGCGGCGCTGAGGATCCTGCAGG
GTGATGGCAAATGA

Structures

Toxin

• AlphaFold DB: A0A1H9I4P8