48823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3557266..3557894 Replicon chromosome
Accession NZ_CP009365
Organism Pseudomonas soli strain SJ10

Toxin (Protein)


Gene name hicA Uniprot ID A0A2L0LXU2
Locus tag O165_RS16465 Protein ID WP_023630766.1
Coordinates 3557712..3557894 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1H9TAW3
Locus tag O165_RS16460 Protein ID WP_023630767.1
Coordinates 3557266..3557691 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O165_RS16435 3552903..3553397 + 495 WP_038706656.1 hypothetical protein -
O165_RS16440 3553402..3553878 + 477 WP_038706657.1 YchJ family protein -
O165_RS16445 3553881..3554357 + 477 WP_023632502.1 LEA type 2 family protein -
O165_RS16450 3554365..3554568 + 204 WP_023632501.1 SEC-C domain-containing protein -
O165_RS16455 3554760..3557195 + 2436 WP_038706658.1 penicillin acylase family protein -
O165_RS16460 3557266..3557691 - 426 WP_023630767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
O165_RS16465 3557712..3557894 - 183 WP_023630766.1 type II toxin-antitoxin system HicA family toxin Toxin
O165_RS16470 3558128..3559243 + 1116 WP_038706659.1 succinylglutamate desuccinylase/aspartoacylase family protein -
O165_RS16475 3559250..3559492 - 243 WP_023630765.1 hypothetical protein -
O165_RS16480 3559590..3560156 - 567 WP_023630764.1 dCTP deaminase -
O165_RS16485 3560484..3560693 + 210 WP_012273869.1 cold-shock protein -
O165_RS16490 3560816..3561910 - 1095 WP_023630763.1 iron-sulfur cluster carrier protein ApbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-69)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6845.93 Da        Isoelectric Point: 10.7459

>T48823 WP_023630766.1 NZ_CP009365:c3557894-3557712 [Pseudomonas soli]
MKYSELRRWLRSQGATFVPAKGSHFKVYLGNRQTIFPDHGAKEIGEGLRKKILKDLGLSD

Download         Length: 183 bp

>T48823 NZ_CP009365:c3557894-3557712 [Pseudomonas soli]
ATGAAGTACAGCGAACTACGTCGATGGCTGCGTTCTCAGGGAGCCACCTTCGTTCCTGCCAAAGGCAGCCATTTCAAGGT
TTACCTGGGCAATCGACAAACCATCTTCCCCGACCACGGCGCCAAGGAAATAGGGGAGGGGCTGAGGAAGAAGATCCTCA
AGGATCTTGGACTGAGCGACTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15449.73 Da        Isoelectric Point: 5.1723

>AT48823 WP_023630767.1 NZ_CP009365:c3557691-3557266 [Pseudomonas soli]
MNFDYPVNVHRDTGSVWISCPDIPEMASAGDTLDEALFDAVDALESALSLYVERRAAIPLPTPVQSAEAIVRLPALTAAK
AALWNTMVSQNVTKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVAA

Download         Length: 426 bp

>AT48823 NZ_CP009365:c3557691-3557266 [Pseudomonas soli]
ATGAATTTCGACTATCCGGTAAACGTGCACCGTGATACAGGCAGTGTCTGGATCAGTTGTCCGGATATACCTGAGATGGC
CAGTGCGGGCGATACGCTCGATGAAGCATTGTTCGATGCAGTGGATGCCCTGGAGTCAGCGCTTTCCCTGTACGTGGAGC
GTCGGGCAGCCATTCCGTTGCCGACACCAGTGCAGTCAGCCGAGGCCATTGTCAGGTTGCCGGCGCTGACCGCGGCCAAG
GCGGCGCTGTGGAACACCATGGTCTCTCAGAACGTGACCAAGACCGAAATGGCCCGACGGCTTGGCGTTAATCGGCCGCA
GGTGGACCGGCTGGTTGATTTGCTGCATCGCTCCAAGATCGAGCAGGTCGAGCATGCCTTGCATGTATTGGGACAACGCA
TAGAACTTGCGGTGGTAGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0LXU2

Antitoxin

Source ID Structure
AlphaFold DB A0A1H9TAW3

References